Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 8/20 | 0.56 |
| ▸ | JAK2 | O60674 | 4/20 | 0.52 |
| ▸ | JAK3 | P52333 | 4/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377043 | 1.00 | ACP1 (0.56) | ACP1JAK2JAK3PTK2FGFR4 | |
| SCHEMBL18376598 | 0.91 | FGFR4 (0.59) | JAK2JAK3PTK2FGFR4AXL | |
| SCHEMBL29371309 | 0.91 | FGFR4 (0.59) | JAK2JAK3PTK2FGFR4AXL | |
| SCHEMBL28687101 | 0.89 | JAK2 (0.49) | ACP1JAK2JAK3PTK2FGFR4 | |
| SCHEMBL18376246 | 0.84 | JAK2 (0.56) | JAK2JAK3PTK2FGFR4BRD4 | |
| SCHEMBL29371334 | 0.84 | JAK2 (0.56) | JAK2JAK3PTK2FGFR4BRD4 | |
| SCHEMBL28696345 | 0.83 | ACP1 (0.47) | ACP1RIPK2 | |
| SCHEMBL29368231 | 0.81 | RIPK2 (0.56) | JAK2FGFR4BRD4RIPK2 | |
| SCHEMBL18376254 | 0.81 | RIPK2 (0.56) | JAK2FGFR4BRD4RIPK2 | |
| SCHEMBL18376603 | 0.81 | FGFR2 (0.51) | JAK2JAK3PTK2BRD4RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |