(+)-Taxifolin

(+)-Taxifolin

SCHEMBL29368246

O=C1c2c(O)cc(O)cc2O[C@@H](c2ccc(O)c(O)c2)[C@@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 1.00
ALOX15 P16050 4/20 1.00
MAPT P10636 3/20 1.00
HSD17B10 Q99714 3/20 1.00
RECQL P46063 2/20 1.00
SOST Q9BQB4 2/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
KDM4E B2RXH2 2/20 1.00
GAA P10253 2/20 1.00
ALOX12 P18054 2/20 1.00
HIF1A Q16665 2/20 1.00
POLB P06746 1/20 1.00
CYP1A2 P05177 1/20 1.00
NFKB1 P19838 1/20 1.00
MAPK1 P28482 1/20 1.00
SYNJ2 O15056 3/20 0.75
APP P05067 1/20 0.75
XDH P47989 2/20 0.67
IDO1 P14902 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Taxifolin SCHEMBL29390633 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL30300501 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL30631315 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL29361519 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL13241264 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL7628142 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL296323 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Epitaxifolin SCHEMBL31575455 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL1707803 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL29367955 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4243809-A2 COMPOUNDS AND METHODS FOR TREATING VIRAL INFECTIONS Beth Israel Deaconess Medical Center, Inc. (US) 2023-09-20 EP claimed
WO-2022104153-A2 COMPOUNDS AND METHODS FOR TREATING VIRAL INFECTIONS BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2022-05-19 WO claimed
CN-114306547-A Traditional Chinese medicine formula for regulating and controlling intestinal function of pregnant women 华子昂 2022-04-12 CN claimed
CN-114272321-A Traditional Chinese medicine formula for regulating and controlling intestinal function of old people 华子昂 2022-04-05 CN claimed
CN-114129680-A Traditional Chinese medicine formula for promoting calcium supplement of postpartum women 华子昂 2022-03-04 CN claimed
WO-2023287620-A9 METHODS FOR TREATING CORONAVIRUS INFECTION RABINOFF MICHAEL (US) 2023-11-30 WO disclosed
WO-2023287620-A9 METHODS FOR TREATING CORONAVIRUS INFECTION RABINOFF MICHAEL (US) 2023-11-30 WO disclosed
WO-2023287620-A1 METHODS FOR TREATING CORONAVIRUS INFECTION RABINOFF MICHAEL (US) 2023-01-19 WO disclosed
WO-2023287620-A1 METHODS FOR TREATING CORONAVIRUS INFECTION RABINOFF MICHAEL (US) 2023-01-19 WO disclosed
US-20220378716-A1 FORMULATION TO REDUCE OR PREVENT OXIDATIVE STRESS DAMAGE Cora Therapeutics Inc. (CA) 2022-12-01 US disclosed
CN-115209892-A Formulations for reducing or preventing oxidative stress damage 科拉医疗股份有限公司 2022-10-18 CN disclosed
EP-4051261-A1 FORMULATION TO REDUCE OR PREVENT OXIDATIVE STRESS DAMAGE Cora Therapeutics Inc. (CA) 2022-09-07 EP disclosed
CN-114306547-A Traditional Chinese medicine formula for regulating and controlling intestinal function of pregnant women 华子昂 2022-04-12 CN disclosed
CN-114272321-A Traditional Chinese medicine formula for regulating and controlling intestinal function of old people 华子昂 2022-04-05 CN disclosed
CN-114129680-A Traditional Chinese medicine formula for promoting calcium supplement of postpartum women 华子昂 2022-03-04 CN disclosed
CN-114007604-A Hepatic fibrosis inhibitor and brown fat cell activator containing taxifolin 独立行政法人国立病院机构 2022-02-01 CN disclosed