(+)-Taxifolin

(+)-Taxifolin

SCHEMBL7628142

O=C1c2c(O)cc(O)cc2O[C@H](c2ccc(O)c(O)c2)C1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 1.00
ALOX15 P16050 4/20 1.00
MAPT P10636 3/20 1.00
HSD17B10 Q99714 3/20 1.00
RECQL P46063 2/20 1.00
SOST Q9BQB4 2/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
KDM4E B2RXH2 2/20 1.00
GAA P10253 2/20 1.00
ALOX12 P18054 2/20 1.00
HIF1A Q16665 2/20 1.00
POLB P06746 1/20 1.00
CYP1A2 P05177 1/20 1.00
NFKB1 P19838 1/20 1.00
MAPK1 P28482 1/20 1.00
SYNJ2 O15056 3/20 0.75
APP P05067 1/20 0.75
XDH P47989 2/20 0.67
IDO1 P14902 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Taxifolin SCHEMBL29390633 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL30300501 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL30631315 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL29361519 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL13241264 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL296323 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL29368246 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Epitaxifolin SCHEMBL31575455 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL1707803 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL
(+)-Taxifolin SCHEMBL29367955 1.00 CYP3A4 (1.00) CYP3A4ALOX15MAPTHSD17B10RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4580594-A1 ANTIOXIDANT COMPOSITION COMPRISING 5-DEOXYFLAVONOIDS AnalytiCon Discovery - Zweigniederlassung der BRAIN Biotech AG (DE) 2025-07-09 EP disclosed
WO-2024046834-A1 ANTIOXIDANT COMPOSITION COMPRISING 5-DEOXYFLAVONOIDS ANALYTICON DISCOVERY GMBH (DE) 2024-03-07 WO disclosed
EP-4331564-A1 ANTIOXIDANT COMPOSITION COMPRISING 5-DEOXYFLAVONOIDS Analyticon Discovery GmbH (DE) 2024-03-06 EP disclosed
CN-109316438-A A kind of preparation method of the solid precursor liposome with acne-removing 珀莱雅化妆品股份有限公司 2019-02-12 CN disclosed
CN-104910121-A Taxifolin preparation method NANJING ZELANG BIOTECHNOLOGY CO LTD 2015-09-16 CN disclosed
US-8536363-B2 Compounds and methods for delivery of prostacyclin analogs UNITED THERAPEUTICS CORPORATION (US) 2013-09-17 US disclosed
US-20120295980-A1 COMPOUNDS AND METHODS FOR DELIVERY OF PROSTACYCLIN ANALOGS UNITED THERAPEUTICS CORPORATION 2012-11-22 US disclosed
WO-2010134580-A1 METHOD FOR PRODUCING AROMATIC FLUORINE COMPOUND AND NOVEL COMPOUND 静岡県公立大学法人 (JP) 2010-11-25 WO disclosed
US-7524836-B2 Nitrooxyderivative steroidal compounds NICOX S.A. (FR) 2009-04-28 US disclosed
US-20070142342-A1 Pharmaceutical compounds NICOX S.A. 2007-06-21 US disclosed
US-7186708-B2 Steroidal compounds NICOX S.A. (FR) 2007-03-06 US disclosed
US-7186708-B2 Steroidal compounds NICOX S.A. (FR) 2007-03-06 US disclosed
EP-1003528-B1 METHOD OF ENHANCING BIOAVAILABILITY OF FEXOFENADINE AND ITS DERIVATIVES AVENTIS PHARMA INC (US) 2002-09-25 EP disclosed
US-6451815-B1 Method of enhancing bioavailability of fexofenadine and its derivatives AVENTIS PHARMACEUTICALS INC. 2002-09-17 US disclosed
EP-1003528-A1 METHOD OF ENHANCING BIOAVAILABILITY OF FEXOFENADINE AND ITS DERIVATIVES Aventis Pharmaceuticals Inc. (US) 2000-05-31 EP disclosed
WO-1999008690-A1 METHOD OF ENHANCING BIOAVAILABILITY OF FEXOFENADINE AND ITS DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1999-02-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070142342-A1 Pharmaceutical compounds CYP11B2, CYP11B1, CYP2S1 CYP3A4 33/4885ALOX15 325/4885MAPT 3031/4885
US-20120295980-A1 COMPOUNDS AND METHODS FOR DELIVERY OF PROSTACYCLIN ANALOGS PTGIS, PGF, PTGIR CYP3A4 1064/4885ALOX15 92/4885MAPT 4707/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.