Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 6/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 4/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | GALR2 | O43603 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377037 | 1.00 | MAPK10 (0.54) | MAPK10TP53JUNACP1APP | |
| SCHEMBL29371294 | 0.91 | MAPK10 (0.60) | MAPK10JUNSYKAURKACCNA2 | |
| SCHEMBL18376750 | 0.91 | MAPK10 (0.60) | MAPK10JUNSYKAURKACCNA2 | |
| SCHEMBL18377036 | 0.86 | MAPK10 (0.55) | MAPK10JUNSYKAURKACCNA2 | |
| SCHEMBL29371938 | 0.86 | MAPK10 (0.55) | MAPK10JUNSYKAURKACCNA2 | |
| SCHEMBL29372241 | 0.85 | PIK3CA (0.57) | MAPK10JUNACP1SYKAURKA | |
| SCHEMBL18377045 | 0.85 | PIK3CA (0.57) | MAPK10JUNACP1SYKAURKA | |
| SCHEMBL18376591 | 0.84 | MAPK10 (0.54) | MAPK10JUNSYKAURKACCNA2 | |
| SCHEMBL29370804 | 0.84 | MAPK10 (0.54) | MAPK10JUNSYKAURKACCNA2 | |
| SCHEMBL18377040 | 0.82 | PIK3CG (0.60) | MAPK10JUNSYKCCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |