Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.55 |
| ▸ | JUN | P05412 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377045 | 1.00 | PIK3CA (0.57) | PIK3CAPIK3CBPIK3CGMAPK10JUN | |
| SCHEMBL18376750 | 0.94 | MAPK10 (0.60) | PIK3CAPIK3CBPIK3CGMAPK10JUN | |
| SCHEMBL29371294 | 0.94 | MAPK10 (0.60) | PIK3CAPIK3CBPIK3CGMAPK10JUN | |
| SCHEMBL29371938 | 0.89 | MAPK10 (0.55) | PIK3CAPIK3CBPIK3CGMAPK10JUN | |
| SCHEMBL18377036 | 0.89 | MAPK10 (0.55) | PIK3CAPIK3CBPIK3CGMAPK10JUN | |
| SCHEMBL29370804 | 0.87 | MAPK10 (0.54) | MAPK10JUNCCNA2CDK2TTK | |
| SCHEMBL18376591 | 0.87 | MAPK10 (0.54) | MAPK10JUNCCNA2CDK2TTK | |
| SCHEMBL29368435 | 0.85 | MAPK10 (0.54) | MAPK10JUNCCNA2CDK2TTK | |
| SCHEMBL18377037 | 0.85 | MAPK10 (0.54) | MAPK10JUNCCNA2CDK2TTK | |
| SCHEMBL18377040 | 0.85 | PIK3CG (0.60) | PIK3CAPIK3CBPIK3CGMAPK10JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |