Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22559658 | 1.00 | KHK (0.54) | KHKNPC1RAB9APAX8HTT | |
| SCHEMBL24852360 | 0.83 | KHK (0.49) | KHKNPC1RAB9APAX8HTT | |
| SCHEMBL31738193 | 0.83 | KHK (0.49) | KHKNPC1RAB9APAX8HTT | |
| SCHEMBL22567093 | 0.83 | KHK (0.67) | KHKNPC1RAB9APAX8HTT | |
| Hydrochloric Acid SCHEMBL22559632 | 0.82 | KHK (0.66) | KHKNPC1RAB9APAX8HTT | |
| Hydrochloric Acid SCHEMBL29397092 | 0.82 | KHK (0.66) | KHKNPC1RAB9APAX8HTT | |
| SCHEMBL22567077 | 0.80 | KHK (0.64) | KHKNPC1RAB9APAX8HTT | |
| SCHEMBL2548808 | 0.77 | KHK (0.56) | KHKNPC1RAB9APAX8HTT | |
| SCHEMBL30464135 | 0.77 | KHK (0.56) | KHKNPC1RAB9APAX8HTT | |
| SCHEMBL23711747 | 0.75 | KHK (0.58) | KHKNPC1RAB9APAX8HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3955914-A1 | NOVEL COMPOUNDS AND METHODS OF USE TREATING FRUCTOSE-RELATED DISORDERS OR DISEASES | Colorado Research Partners, LLC (US) | 2022-02-23 | — | — | EP | disclosed |
| CN-114007602-A | Novel compounds and methods of use for treating fructose-related disorders or diseases | 科罗拉多研究合作伙伴有限责任公司 | 2022-02-01 | — | — | CN | disclosed |