Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 12/20 | 1.00 |
| ▸ | BMPR1A | P36894 | 12/20 | 1.00 |
| ▸ | TGFBR1 | P36897 | 12/20 | 1.00 |
| ▸ | ACVRL1 | P37023 | 12/20 | 1.00 |
| ▸ | ACVR1 | Q04771 | 12/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.59 |
| ▸ | CNR2 | P34972 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | MERTK | Q12866 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19806967 | 1.00 | BMPR1B (1.00) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL19806958 | 0.93 | BMPR1B (1.00) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL29373193 | 0.93 | BMPR1B (1.00) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL30508412 | 0.90 | BMPR1B (0.82) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL29042031 | 0.90 | BMPR1B (0.82) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL23940733 | 0.84 | BMPR1B (0.73) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL19807041 | 0.84 | BMPR1B (0.73) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL30508278 | 0.83 | BMPR1B (0.70) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL29370273 | 0.82 | BMPR1B (1.00) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL19807004 | 0.82 | BMPR1B (1.00) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114014844-B | Aminopyridine derivatives and their use as selective ALK-2 inhibitors | 诺华股份有限公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-114014844-A | Aminopyridine derivatives and their use as selective ALK-2 inhibitors | 诺华股份有限公司 | 2022-02-08 | — | — | CN | disclosed |