Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 20/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255376 | 1.00 | CFTR (0.64) | CFTRNR1I2ADORA3CYP2C8CYP2C9 | |
| SCHEMBL2927265 | 0.94 | CFTR (0.64) | CFTRNR1I2ADORA3CYP2C8CYP2C9 | |
| SCHEMBL20171802 | 0.93 | CFTR (0.58) | CFTRNR1I2ADORA3CYP2C8CYP2C9 | |
| Hydrochloric Acid SCHEMBL17074569 | 0.93 | CFTR (0.63) | CFTRNR1I2ADORA3CYP2C8CYP2C9 | |
| SCHEMBL3040343 | 0.92 | CFTR (0.76) | CFTRNR1I2ADORA3CYP2C8CYP2C9 | |
| SCHEMBL25917885 | 0.92 | CFTR (0.59) | CFTRNR1I2ADORA3CYP2C8CYP2C9 | |
| SCHEMBL3042594 | 0.92 | CFTR (0.57) | CFTRNR1I2ADORA3CYP2C8CYP2C9 | |
| SCHEMBL20628576 | 0.92 | CFTR (0.59) | CFTRNR1I2ADORA3CYP2C8CYP2C9 | |
| SCHEMBL19418866 | 0.90 | CFTR (0.55) | CFTRNR1I2ADORA3CYP2C8CYP2C9 | |
| SCHEMBL4173401 | 0.90 | CFTR (0.55) | CFTRNR1I2ADORA3CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233560-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-07-27 | — | — | US | disclosed |
| EP-4188365-A2 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) MODULATORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Emory University (US) | 2023-06-07 | — | — | EP | disclosed |
| EP-3798214-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2022-09-14 | — | — | EP | disclosed |
| CN-110840847-B | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2022-07-29 | — | — | CN | disclosed |
| WO-2022026863-A2 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) MODULATORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | EMORY UNIVERSITY (US) | 2022-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233560-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1B, SLC26A4 | CFTR 1/4885NR1I2 767/4885ADORA3 514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.