Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2937248 | 1.00 | IGF1R (0.51) | IGF1RMAPK1KMT2ANTRK1 | |
| Trifluoroacetic Acid SCHEMBL3727093 | 0.95 | IGF1R (0.47) | IGF1RMAPK1KMT2ANTRK1 | |
| SCHEMBL2940631 | 0.89 | IGF1R (0.53) | IGF1R | |
| SCHEMBL2940635 | 0.89 | IGF1R (0.53) | IGF1R | |
| SCHEMBL2941750 | 0.86 | IGF1R (0.50) | IGF1R | |
| SCHEMBL2941751 | 0.86 | IGF1R (0.50) | IGF1R | |
| Trifluoroacetic Acid SCHEMBL3736477 | 0.85 | IGF1R (0.49) | IGF1R | |
| SCHEMBL2940864 | 0.85 | IGF1R (0.72) | IGF1RMAPK1KMT2A | |
| SCHEMBL2940866 | 0.85 | IGF1R (0.72) | IGF1RMAPK1KMT2A | |
| SCHEMBL2941625 | 0.83 | IGF1R (0.72) | IGF1RNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |