Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 18/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2297565 | 0.95 | PTGER4 (0.72) | PTGER4CYP1A2CYP2D6THRB | |
| SCHEMBL9947684 | 0.92 | PTGER4 (0.57) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL10058539 | 0.90 | PTGER4 (0.54) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL2929004 | 0.90 | PTGER4 (0.66) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL12325238 | 0.90 | PTGER4 (0.52) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL13942572 | 0.89 | PTGER4 (0.65) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL9948021 | 0.89 | PTGER4 (0.51) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL1590138 | 0.89 | PTGER4 (0.64) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL2431846 | 0.89 | PTGER4 (0.64) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL3231403 | 0.89 | PTGER4 (0.64) | PTGER4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979317-B1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LTD (GB) | 2012-08-22 | — | — | EP | disclosed |
| US-8207213-B2 | Benzoisoindole derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2012-06-26 | — | — | US | disclosed |
| EP-2046742-B1 | BENZO [F] ISOINDOLES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2010-09-22 | — | — | EP | disclosed |
| US-20100069457-A1 | Naphthalene Derivatives Used As EP4 Receptor Agonists | GLAXO GROUP LIMITED (GB) | 2010-03-18 | — | — | US | disclosed |
| US-20090312388-A1 | Benzo [F] Isoindoles As EP4 Receptor Agonists | GLAXO GROUP LIMITED | 2009-12-17 | — | — | US | disclosed |
| EP-2049485-A1 | NAPHTHALENE DERIVATIVES USED AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2009-04-22 | — | — | EP | disclosed |
| EP-2046742-A1 | BENZO [F] ISOINDOLES AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008012344-A1 | NAPHTHALENE DERIVATIVES USED AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-01-31 | — | — | WO | disclosed |
| WO-2008012347-A1 | BENZO [F] ISOINDOLES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312388-A1 | Benzo [F] Isoindoles As EP4 Receptor Agonists | PTGER4, GPR4, PTGER1 | PTGER4 1/4885CYP1A2 310/4885CYP2D6 393/4885 |
| US-20100069457-A1 | Naphthalene Derivatives Used As EP4 Receptor Agonists | PTGER4, PTGER1, PTGER3 | PTGER4 1/4885CYP1A2 293/4885CYP2D6 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.