Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 9/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.40 |
| ▸ | NRAS | P01111 | 4/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24231440 | 1.00 | EIF2AK4 (0.47) | EIF2AK4FLT3GABRA1GABRG2GABRB3 | |
| SCHEMBL29370124 | 0.90 | FLT3 (0.46) | EIF2AK4FLT3GABRA1GABRG2GABRB3 | |
| SCHEMBL24231773 | 0.90 | FLT3 (0.46) | EIF2AK4FLT3GABRA1GABRG2GABRB3 | |
| SCHEMBL31068067 | 0.84 | GABRA1 (0.48) | EIF2AK4FLT3GABRA1GABRG2GABRB3 | |
| SCHEMBL24574150 | 0.84 | GABRA1 (0.48) | EIF2AK4FLT3GABRA1GABRG2GABRB3 | |
| SCHEMBL24231689 | 0.81 | GABRA1 (0.49) | FLT3GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL29373972 | 0.81 | GABRA1 (0.49) | FLT3GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL26358849 | 0.80 | FLT3 (0.49) | FLT3GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL24573963 | 0.78 | GABRA1 (0.50) | EIF2AK4FLT3GABRA1GABRG2GABRB3 | |
| SCHEMBL30638516 | 0.78 | GABRA1 (0.50) | EIF2AK4FLT3GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022026935-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2022-02-03 | — | — | WO | disclosed |