Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | PAK4 | O96013 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | FLT1 | P17948 | 1/20 | 0.60 |
| ▸ | LTK | P29376 | 1/20 | 0.60 |
| ▸ | GRK5 | P34947 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.60 |
| ▸ | CDK8 | P49336 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL842776 | 1.00 | GSK3B (0.60) | GSK3BRPS6KA3CHEK1AURKADAPK3 | |
| SCHEMBL11070341 | 0.89 | CDC7 (0.53) | GSK3BRPS6KA3CHEK1AURKADAPK3 | |
| SCHEMBL30980399 | 0.84 | CDK8 (0.65) | GSK3BRPS6KA3CHEK1AURKADAPK3 | |
| SCHEMBL162420 | 0.84 | CDK8 (0.65) | GSK3BRPS6KA3CHEK1AURKADAPK3 | |
| SCHEMBL4405770 | 0.79 | BCL2L1 (0.57) | DYRK1APTPN2MAPTGAAALDH1A1 | |
| SCHEMBL29913871 | 0.79 | BCL2L1 (0.57) | DYRK1APTPN2MAPTGAAALDH1A1 | |
| SCHEMBL13977223 | 0.79 | DYRK1A (0.71) | GSK3BRPS6KA3CHEK1AURKADAPK3 | |
| SCHEMBL2238245 | 0.78 | PTPN2 (0.60) | CDC7DBF4PTPN2MAPTGAA | |
| SCHEMBL8250276 | 0.78 | HDAC1 (0.60) | PTPN2MAPTGAAALDH1A1PKM | |
| SCHEMBL26564672 | 0.78 | CHEK1 (0.65) | GSK3BRPS6KA3CHEK1AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116730995-B | Hydrazide compound, preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-109096274-B | Biaryl compounds useful in the treatment of human oncological, neurological and immunological diseases | 比奥根MA公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-108570059-B | Compound with PRMT5 inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2022-02-08 | — | — | CN | disclosed |