Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 7/20 | 0.53 |
| ▸ | DBF4 | Q9UBU7 | 7/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29374201 | 0.89 | GSK3B (0.60) | CDC7DBF4MAPK14GSK3BRPS6KA3 | |
| SCHEMBL842776 | 0.89 | GSK3B (0.60) | CDC7DBF4MAPK14GSK3BRPS6KA3 | |
| SCHEMBL160500 | 0.84 | CDK8 (0.49) | HDAC3HDAC1HDAC2NCOR2GSK3B | |
| SCHEMBL2010041 | 0.81 | HDAC1 (0.49) | HDAC3HDAC1HDAC2NCOR2GSK3B | |
| SCHEMBL21129497 | 0.80 | HDAC1 (0.41) | CDC7DBF4HDAC3HDAC1HDAC2 | |
| SCHEMBL3498715 | 0.80 | MMP2 (0.59) | CDC7DBF4MAPK14HDAC3HDAC1 | |
| SCHEMBL4405770 | 0.79 | BCL2L1 (0.57) | HDAC3HDAC1HDAC2DYRK1APTPN2 | |
| SCHEMBL29913871 | 0.79 | BCL2L1 (0.57) | HDAC3HDAC1HDAC2DYRK1APTPN2 | |
| SCHEMBL2009820 | 0.79 | DYRK1A (0.56) | MAPK14HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL2238245 | 0.78 | PTPN2 (0.60) | CDC7DBF4HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116730995-B | Hydrazide compound, preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| EP-3480193-B1 | PYRAZOLE DERIVATIVES AS ALK5 INHIBITORS AND USES THEREOF | HANMI PHARMACEUTICAL CO LTD (KR) | 2024-05-29 | — | — | EP | disclosed |
| US-10954232-B2 | Pyrazole derivative as ALK5 inhibitor and uses thereof | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2021-03-23 | — | — | US | disclosed |
| US-10954232-B2 | Pyrazole derivative as ALK5 inhibitor and uses thereof | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2021-03-23 | — | — | US | disclosed |
| US-20190194198-A1 | NOVEL PYRAZOLE DERIVATIVE AS ALK5 INHIBITOR AND USES THEREOF | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2019-06-27 | — | — | US | disclosed |
| US-20190194198-A1 | NOVEL PYRAZOLE DERIVATIVE AS ALK5 INHIBITOR AND USES THEREOF | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2019-06-27 | — | — | US | disclosed |
| EP-3480193-A1 | NOVEL PYRAZOLE DERIVATIVE AS ALK5 INHIBITOR AND USES THEREOF | Hanmi Pharmaceutical Co., Ltd. (KR) | 2019-05-08 | — | — | EP | disclosed |
| US-4480098-A | Preparation of alkali metal thieno(furo)pyridines | ELI LILLY AND COMPANY (US) | 1984-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194198-A1 | NOVEL PYRAZOLE DERIVATIVE AS ALK5 INHIBITOR AND USES THEREOF | ALK, SMAD3, TGFBR1 | CDC7 1263/4885DBF4 2626/4885MAPK14 190/4885 |
| US-10954232-B2 | Pyrazole derivative as ALK5 inhibitor and uses thereof | ALK, SMAD3, TGFBR1 | CDC7 1239/4885DBF4 2895/4885MAPK14 216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.