Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 17/20 | 0.55 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.55 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929076 | 0.88 | S1PR1 (0.56) | S1PR1S1PR3S1PR5MAP4K4MINK1 | |
| SCHEMBL2930307 | 0.88 | MAP4K4 (0.59) | S1PR1S1PR3S1PR5MAP4K4MINK1 | |
| SCHEMBL2934787 | 0.85 | S1PR1 (0.53) | S1PR1S1PR3S1PR5MAP4K4MINK1 | |
| SCHEMBL2927103 | 0.80 | S1PR1 (0.56) | S1PR1S1PR3S1PR5 | |
| SCHEMBL2935613 | 0.78 | S1PR1 (0.44) | S1PR1S1PR3S1PR5MAP4K4MINK1 | |
| SCHEMBL2930303 | 0.76 | MAP4K4 (0.61) | S1PR1S1PR3S1PR5MAP4K4MINK1 | |
| SCHEMBL2937791 | 0.75 | S1PR1 (0.45) | S1PR1S1PR3S1PR5S1PR4NR1H4 | |
| SCHEMBL2807560 | 0.75 | S1PR1 (0.58) | S1PR1S1PR3S1PR5MAP4K4MINK1 | |
| SCHEMBL2933666 | 0.74 | S1PR1 (0.64) | S1PR1S1PR5 | |
| SCHEMBL12808935 | 0.74 | S1PR1 (0.59) | S1PR1S1PR3S1PR5MAP4K4MINK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091950-B1 | OXADIAZOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2010-09-22 | — | — | EP | claimed |