Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | CTSV | O60911 | 2/20 | 0.55 |
| ▸ | CTSL | P07711 | 2/20 | 0.55 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.52 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2990559 | 1.00 | KDM4E (0.57) | KDM4EALDH1A1HPGDHDAC8CTSV | |
| SCHEMBL8202692 | 0.91 | KDM4E (0.64) | KDM4EALDH1A1HPGDCTSVCTSL | |
| SCHEMBL629641 | 0.90 | SLC16A3 (0.62) | KDM4EALDH1A1HPGDCTSVCTSL | |
| SCHEMBL8204838 | 0.90 | HDAC8 (0.53) | KDM4EHPGDHDAC8CTSVCTSL | |
| SCHEMBL29376294 | 0.88 | HDAC8 (0.52) | ALDH1A1HDAC8FLT3APPLRRK2 | |
| SCHEMBL2996551 | 0.88 | HDAC8 (0.52) | ALDH1A1HDAC8FLT3APPLRRK2 | |
| SCHEMBL1647498 | 0.87 | FOLH1 (0.63) | KDM4EALDH1A1HDAC8CTSVCTSL | |
| SCHEMBL7273836 | 0.87 | FOLH1 (0.61) | KDM4EALDH1A1HPGDCTSVCTSL | |
| SCHEMBL31550547 | 0.86 | HDAC8 (0.60) | KDM4EHDAC8CTSVCTSLFOLH1 | |
| SCHEMBL6404086 | 0.86 | HDAC8 (0.60) | KDM4EHDAC8CTSVCTSLFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116348455-A | Protein tyrosine phosphatase inhibitors and methods of use thereof | 卡里科生命科学有限责任公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-116332873-A | Protein tyrosine phosphatase inhibitors and methods of use thereof | 卡里科生命科学有限责任公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-114025844-B | Protein tyrosine phosphatase inhibitors and methods of use thereof | 卡里科生命科学有限责任公司 | 2022-07-26 | — | — | CN | disclosed |
| CN-114025844-A | Protein tyrosine phosphatase inhibitors and methods of use thereof | 卡里科生命科学有限责任公司 | 2022-02-08 | — | — | CN | disclosed |