Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16973636 | 1.00 | KDM4E (0.56) | KDM4ENPC1MAPTPKMRAB9A | |
| SCHEMBL21824326 | 0.92 | NPC1 (0.47) | KDM4ENPC1MAPTPKMRAB9A | |
| SCHEMBL29521804 | 0.81 | KDM4E (0.46) | KDM4ENPC1MAPTPKMRAB9A | |
| SCHEMBL23060734 | 0.80 | KDM4E (0.44) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL29374541 | 0.80 | SMN1; SMN2 (0.40) | KDM4ERAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL16973490 | 0.80 | SMN1; SMN2 (0.40) | KDM4ERAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL30137683 | 0.79 | KDM4E (0.42) | KDM4EMAPTALDH1A1L3MBTL1 | |
| SCHEMBL30607727 | 0.79 | NAPRT (0.37) | KDM4ENPC1MAPTPKMRAB9A | |
| SCHEMBL24022985 | 0.78 | ALDH1A1 (0.44) | KDM4ENPC1MAPTPKMRAB9A | |
| SCHEMBL21824307 | 0.77 | NOTUM (0.36) | KDM4EPKMALDH1A1L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320117-A2 | NOVEL HEPATOSELECTIVE POLYADENYLATING POLYMERASES INHIBITORS AND THEIR METHOD OF USE | Baruch S. Blumberg Institute (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-114014854-B | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-113999224-B | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2023-04-07 | — | — | CN | disclosed |
| WO-2022216552-A2 | NOVEL HEPATOSELECTIVE POLYADENYLATING POLYMERASES INHIBITORS AND THEIR METHOD OF USE | BARUCH S. BLUMBERG INSTITUTE (US) | 2022-10-13 | — | — | WO | disclosed |
| CN-109715624-B | Novel therapeutic agents for the treatment of HBV infection | 广州麓鹏制药有限公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-114014854-A | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2022-02-08 | — | — | CN | disclosed |
| CN-110177785-B | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2022-02-08 | — | — | CN | disclosed |