SCHEMBL29377191

SCHEMBL29377191

O=C(O)c1cc2c(nc1Cl)CCC2

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.51
KEAP1 Q14145 1/20 0.47
NFE2L2 Q16236 1/20 0.47
SMN1; SMN2 Q16637 5/20 0.46
KDM4E B2RXH2 3/20 0.41
SLC9A1 P19634 1/20 0.41
ALDH1A1 P00352 4/20 0.41
MAPT P10636 3/20 0.41
LMNA P02545 2/20 0.41
MAPK1 P28482 2/20 0.41
TP53 P04637 1/20 0.41
HTT P42858 1/20 0.41
HSP90AA1 P07900 1/20 0.40
HPGD P15428 1/20 0.40
HSD17B10 Q99714 1/20 0.40
RECQL P46063 1/20 0.39
CASP6 P55212 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
NPC1 O15118 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL682462 1.00 POLB (0.51) POLBKEAP1NFE2L2SMN1; SMN2KDM4E
SCHEMBL25281642 0.97 POLB (0.51) POLBKEAP1NFE2L2SMN1; SMN2KDM4E
SCHEMBL19454422 0.86 SMN1; SMN2 (0.46) POLBSMN1; SMN2KDM4ESLC9A1ALDH1A1
SCHEMBL12721711 0.85 SMN1; SMN2 (0.47) POLBSMN1; SMN2KDM4ESLC9A1ALDH1A1
SCHEMBL17675596 0.83 SMN1; SMN2 (0.50) POLBSMN1; SMN2KDM4ESLC9A1ALDH1A1
SCHEMBL23105205 0.81 SMN1; SMN2 (0.49) POLBSMN1; SMN2KDM4ESLC9A1ALDH1A1
SCHEMBL24517228 0.81 KDM4E (0.47) POLBSMN1; SMN2KDM4ESLC9A1ALDH1A1
SCHEMBL29378235 0.81 KDM4E (0.47) POLBSMN1; SMN2KDM4ESLC9A1ALDH1A1
SCHEMBL20619534 0.81 KDM4E (0.42) SMN1; SMN2KDM4ESLC9A1ALDH1A1MAPT
SCHEMBL30681913 0.81 KDM4E (0.42) SMN1; SMN2KDM4ESLC9A1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119585247-A Bicyclic heterocyclic amide inhibitors of nav1.8 for the treatment of pain 赛特温治疗公司 2025-03-07 CN disclosed
EP-4514789-A1 <SUP2/>? <SUB2/>?V?BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA1.8 FOR THE TREATMENT OF PAIN SiteOne Therapeutics, Inc. (US) 2025-03-05 EP disclosed
CN-119365455-A Having a bromodomain active compounds 纽韦卢森公司 2025-01-24 CN disclosed
CN-112689633-B For inhibiting Nav1.8 Pyridinecarboxamide Compounds 利伯研究所公司 2025-01-24 CN disclosed
EP-4448494-A1 NOVEL SUBSTITUTED FUSED BICYCLIC PYRIDINE CARBOXAMIDE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI Industries Ltd. (IN) 2024-10-23 EP disclosed
WO-2023211990-A1 BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN SITEONE THERAPEUTICS, INC. (US) 2023-11-02 WO disclosed
WO-2023112056-A1 NOVEL SUBSTITUTED FUSED BICYCLIC PYRIDINE CARBOXAMIDE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2023-06-22 WO disclosed
EP-4192816-A1 COMPOUNDS AS C5AR INHIBITORS Kira Pharmaceuticals (Suzhou) Ltd. (CN) 2023-06-14 EP disclosed
WO-2022028586-A1 COMPOUNDS AS C5AR INHIBITORS KIRA PHARMACEUTICALS (SUZHOU) LTD. (CN) 2022-02-10 WO disclosed