Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | EEF2K | O00418 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23105205 | 0.98 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4ESLC9A1ALDH1A1MAPT | |
| SCHEMBL19454422 | 0.97 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4ESLC9A1ALDH1A1MAPT | |
| SCHEMBL25281642 | 0.86 | POLB (0.51) | SMN1; SMN2KDM4ESLC9A1ALDH1A1MAPT | |
| SCHEMBL29377191 | 0.83 | POLB (0.51) | SMN1; SMN2KDM4ESLC9A1ALDH1A1MAPT | |
| SCHEMBL682462 | 0.83 | POLB (0.51) | SMN1; SMN2KDM4ESLC9A1ALDH1A1MAPT | |
| SCHEMBL12721711 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4ESLC9A1ALDH1A1MAPT | |
| SCHEMBL9871030 | 0.81 | KDM4E (0.50) | SMN1; SMN2KDM4ESLC9A1ALDH1A1MAPT | |
| SCHEMBL7913301 | 0.80 | KDM4E (0.49) | SMN1; SMN2KDM4ESLC9A1ALDH1A1MAPT | |
| SCHEMBL30681912 | 0.80 | KDM4E (0.49) | SMN1; SMN2KDM4ESLC9A1ALDH1A1MAPT | |
| SCHEMBL26618036 | 0.80 | KDM4E (0.49) | SMN1; SMN2KDM4ESLC9A1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10626126-B2 | Compounds | PULMOCIDE LIMITED (GB) | 2020-04-21 | — | — | US | disclosed |
| US-10626126-B2 | Compounds | PULMOCIDE LIMITED (GB) | 2020-04-21 | — | — | US | disclosed |
| US-20190092791-A1 | COMPOUNDS | PULMOCIDE LIMITED (GB) | 2019-03-28 | — | — | US | disclosed |
| US-20190092791-A1 | COMPOUNDS | PULMOCIDE LIMITED (GB) | 2019-03-28 | — | — | US | disclosed |
| US-10189863-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives | PULMOCIDE LIMITED (GB) | 2019-01-29 | — | — | US | disclosed |
| US-10189863-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives | PULMOCIDE LIMITED (GB) | 2019-01-29 | — | — | US | disclosed |
| EP-3204388-B1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVES | PULMOCIDE LTD (GB) | 2018-12-12 | — | — | EP | disclosed |
| US-20170355717-A1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVES | PULMOCIDE LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
| US-20170355717-A1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVES | PULMOCIDE LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
| US-20170355717-A1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVES | PULMOCIDE LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
| WO-2017175000-A1 | COMPOUNDS | PULMOCIDE LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |
| WO-2017175000-A1 | COMPOUNDS | PULMOCIDE LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |
| EP-3204388-A1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVES | Pulmocide Limited (GB) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016055792-A1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVES | PULMOCIDE LIMITED (GB) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016055792-A1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVES | PULMOCIDE LIMITED (GB) | 2016-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10626126-B2 | Compounds | QDPR, TXNRD2, TXNRD3 | SMN1; SMN2 239/4885KDM4E 1377/4885SLC9A1 3383/4885 |
| US-10189863-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives | AZI2, HRH4, ZC3HAV1 | SMN1; SMN2 347/4885KDM4E 364/4885SLC9A1 3936/4885 |
| US-20190092791-A1 | COMPOUNDS | QDPR, TXNRD2, TXNRD3 | SMN1; SMN2 239/4885KDM4E 1377/4885SLC9A1 3383/4885 |
| US-20170355717-A1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVES | ZC3HAV1, DHX15, AZI2 | SMN1; SMN2 560/4885KDM4E 383/4885SLC9A1 3979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.