Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2937762 | 1.00 | IGF1R (0.50) | IGF1RHDAC6PTGS2KMT2APTGS1 | |
| Trifluoroacetic Acid SCHEMBL3723547 | 0.95 | IGF1R (0.46) | IGF1RHDAC6KMT2ASMOTP53 | |
| SCHEMBL2937103 | 0.87 | IGF1R (0.69) | IGF1RPTGS2KMT2APTGS1MAPT | |
| SCHEMBL2937105 | 0.87 | IGF1R (0.69) | IGF1RPTGS2KMT2APTGS1MAPT | |
| SCHEMBL2940931 | 0.85 | IGF1R (0.50) | IGF1RHDAC6SMOTP53GAA | |
| SCHEMBL2940925 | 0.85 | IGF1R (0.50) | IGF1RHDAC6SMOTP53GAA | |
| Trifluoroacetic Acid SCHEMBL3730823 | 0.83 | IGF1R (0.63) | IGF1RKMT2APTGDR2MEN1 | |
| Trifluoroacetic Acid SCHEMBL3728810 | 0.81 | IGF1R (0.42) | IGF1RHDAC6KMT2ATP53MAPT | |
| Trifluoroacetic Acid SCHEMBL3724828 | 0.81 | HDAC6 (0.47) | IGF1RHDAC6SMOTP53GAA | |
| SCHEMBL2939939 | 0.79 | IGF1R (0.44) | IGF1RHDAC6KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |