Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.46 |
| ▸ | SMO | Q99835 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2940931 | 1.00 | IGF1R (0.50) | IGF1RHDAC6SMOHDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL3724828 | 0.95 | HDAC6 (0.47) | IGF1RHDAC6SMOHDAC1HDAC2 | |
| SCHEMBL2939939 | 0.90 | IGF1R (0.44) | IGF1RHDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL2939941 | 0.90 | IGF1R (0.44) | IGF1RHDAC6HDAC1HDAC2HDAC8 | |
| Trifluoroacetic Acid SCHEMBL3728277 | 0.88 | HDAC6 (0.42) | IGF1RHDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL2937762 | 0.85 | IGF1R (0.50) | IGF1RHDAC6SMOGAATP53 | |
| SCHEMBL2937759 | 0.85 | IGF1R (0.50) | IGF1RHDAC6SMOGAATP53 | |
| SCHEMBL3728275 | 0.85 | IGF1R (0.41) | IGF1RHDAC6GAATP53LMNA | |
| SCHEMBL2931273 | 0.83 | IGF1R (0.74) | IGF1RHDAC6SMOHDAC1HDAC2 | |
| SCHEMBL2931269 | 0.83 | IGF1R (0.74) | IGF1RHDAC6SMOHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |