Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | TAS2R8 | Q9NYW2 | 4/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3730514 | 0.93 | IGF1R (0.42) | IGF1RENPP2PTGS2SCN9ASCN10A | |
| SCHEMBL3728965 | 0.91 | IGF1R (0.41) | IGF1RENPP2SCN9ATAS2R8PPARD | |
| SCHEMBL3093717 | 0.87 | CYP11B1 (0.36) | ENPP2GABRA1GABRB2SCN9ASCN10A | |
| SCHEMBL2939355 | 0.83 | ENPP2 (0.43) | IGF1RENPP2PTGS2SCN9ATAS2R8 | |
| SCHEMBL2938826 | 0.80 | IGF1R (0.41) | IGF1RENPP2SCN9ATAS2R8PPARD | |
| SCHEMBL2937993 | 0.80 | IGF1R (0.40) | IGF1RENPP2PTGS2SCN9ATAS2R8 | |
| SCHEMBL2938324 | 0.80 | IGF1R (0.42) | IGF1RENPP2PTGS2SCN9ATAS2R8 | |
| SCHEMBL2940658 | 0.80 | IGF1R (0.40) | IGF1RENPP2PTGS2TAS2R8 | |
| SCHEMBL2931172 | 0.79 | IGF1R (0.42) | IGF1RENPP2PTGS2SCN9ATAS2R8 | |
| SCHEMBL3727186 | 0.79 | ABL1 (0.37) | ENPP2SCN9ASCN10ATAS2R8PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |