Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 known ✓ | O60674 | 20/20 | 0.59 |
| ▸ | JAK1 known ✓ | P23458 | 15/20 | 0.59 |
| ▸ | JAK3 known ✓ | P52333 | 8/20 | 0.59 |
| ▸ | TYK2 known ✓ | P29597 | 3/20 | 0.59 |
| ▸ | KIT known ✓ | P10721 | 1/20 | 0.51 |
| ▸ | FGFR1 known ✓ | P11362 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.51 |
| ▸ | PAK4 | O96013 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | LTK | P29376 | 2/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.51 |
| ▸ | CLK2 | P49760 | 2/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99776 | 0.95 | JAK2 (0.55) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL31419838 | 0.95 | JAK2 (0.55) | JAK2JAK1JAK3TYK2RET | |
| Ruxolitinib SCHEMBL29357426 | 0.74 | JAK2 (1.00) | JAK2JAK1JAK3TYK2RET | |
| Ruxolitinib SCHEMBL29677819 | 0.74 | JAK2 (1.00) | JAK2JAK1JAK3TYK2RET | |
| Ruxolitinib SCHEMBL31073616 | 0.74 | JAK2 (1.00) | JAK2JAK1JAK3TYK2RET | |
| Ruxolitinib SCHEMBL1369365 | 0.74 | JAK2 (1.00) | JAK2JAK1JAK3TYK2RET | |
| Phosphoric Acid SCHEMBL30338770 | 0.74 | JAK2 (0.68) | JAK2JAK1JAK3TYK2RET | |
| Ruxolitinib SCHEMBL1371422 | 0.74 | JAK2 (1.00) | JAK2JAK1JAK3TYK2RET | |
| Phosphoric Acid SCHEMBL28725937 | 0.73 | JAK2 (0.55) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL13678272 | 0.73 | JAK2 (0.55) | JAK2JAK1JAK3TYK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114044777-B | Preparation method of tricitabinib phosphate | 南京佰麦生物技术有限公司 | 2022-04-19 | — | — | CN | disclosed |
| CN-114044777-A | Preparation method of tricitabinib phosphate | 南京佰麦生物技术有限公司 | 2022-02-15 | — | — | CN | disclosed |