Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 4/20 | 0.64 |
| ▸ | KDM4B | O94953 | 4/20 | 0.64 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.64 |
| ▸ | KDM5C | P41229 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.59 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663231 | 1.00 | KDM4A (0.64) | KDM4AKDM4BKDM5BKDM5CMEN1 | |
| SCHEMBL29978012 | 0.91 | GRM1 (0.73) | KDM4AKDM4BKDM5BKDM5CMEN1 | |
| SCHEMBL662995 | 0.91 | GRM1 (0.73) | KDM4AKDM4BKDM5BKDM5CMEN1 | |
| SCHEMBL663246 | 0.91 | MEN1 (0.71) | KDM4AKDM4BKDM5BKDM5CMEN1 | |
| SCHEMBL19763217 | 0.90 | ADORA3 (0.74) | KDM4AKDM4BKDM5BKDM5CMEN1 | |
| SCHEMBL664672 | 0.89 | ADORA3 (0.73) | KDM4AKDM4BKDM5BKDM5CMEN1 | |
| SCHEMBL29977937 | 0.89 | ADORA3 (0.73) | KDM4AKDM4BKDM5BKDM5CMEN1 | |
| SCHEMBL29978560 | 0.88 | ADORA3 (0.75) | KDM4AKDM4BKDM5BKDM5CMEN1 | |
| SCHEMBL664225 | 0.88 | ADORA3 (0.75) | KDM4AKDM4BKDM5BKDM5CMEN1 | |
| SCHEMBL18230323 | 0.86 | ADORA3 (0.79) | KDM4AKDM4BKDM5BKDM5CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022031952-A9 | TREATMENTS FOR CANCERS HAVING KRAS MUTATIONS | CITY OF HOPE (US) | 2022-04-07 | — | — | WO | disclosed |
| WO-2022031952-A2 | TREATMENTS FOR CANCERS HAVING KRAS MUTATIONS | CITY OF HOPE (US) | 2022-02-10 | — | — | WO | disclosed |