Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ramelteon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A known ✓ | P48039 | 20/20 | 1.00 |
| ▸ | MTNR1B known ✓ | P49286 | 20/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | NQO2 | P16083 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R)-Ramelteon SCHEMBL1566122 | 1.00 | MTNR1A (1.00) | MTNR1AMTNR1BABCB11SIGMAR1USP2 | |
| Ramelteon SCHEMBL29237 | 1.00 | MTNR1A (1.00) | MTNR1AMTNR1BABCB11SIGMAR1USP2 | |
| (R)-Ramelteon SCHEMBL29827337 | 1.00 | MTNR1A (1.00) | MTNR1AMTNR1BABCB11SIGMAR1USP2 | |
| (R)-Ramelteon SCHEMBL338730 | 1.00 | MTNR1A (1.00) | MTNR1AMTNR1BABCB11SIGMAR1USP2 | |
| SCHEMBL1566589 | 0.91 | MTNR1A (1.00) | MTNR1AMTNR1BABCB11SIGMAR1USP2 | |
| SCHEMBL1567007 | 0.88 | MTNR1A (1.00) | MTNR1AMTNR1BABCB11SIGMAR1USP2 | |
| SCHEMBL1567415 | 0.88 | MTNR1A (1.00) | MTNR1AMTNR1BABCB11SIGMAR1USP2 | |
| SCHEMBL3065294 | 0.87 | MTNR1A (1.00) | MTNR1AMTNR1BABCB11SIGMAR1USP2 | |
| SCHEMBL13985044 | 0.86 | MTNR1A (0.76) | MTNR1AMTNR1BABCB11SIGMAR1USP2 | |
| SCHEMBL1612991 | 0.85 | MTNR1A (0.78) | MTNR1AMTNR1BABCB11SIGMAR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119950417-A | Rametidine liquid preparation and preparation method and application thereof | 湖南慧泽生物医药科技有限公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-119775240-A | Rametidine in Process for the preparation of intermediates | 广东赛烽医药科技有限公司 | 2025-04-08 | — | — | CN | disclosed |
| WO-2025041809-A1 | METHOD FOR PRODUCING DEUTERATED COMPOUND | 国立大学法人九州大学 | 2025-02-27 | — | — | WO | disclosed |
| CN-118546047-B | Preparation method of cyclic chiral nitrile compound and application of cyclic chiral nitrile compound in preparation of ramelteon | 北京师范大学 | 2025-02-07 | — | — | CN | disclosed |
| EP-4502609-A2 | DETERMINING A CIRCADIAN RHYTHM | Vanda Pharmaceuticals Inc. (US) | 2025-02-05 | — | — | EP | disclosed |
| CN-118546047-A | Preparation method of cyclic chiral nitrile compound and application of cyclic chiral nitrile compound in preparation of ramelteon | 北京师范大学 | 2024-08-27 | — | — | CN | disclosed |
| CN-118384118-A | Ramelteon freeze-dried orally disintegrating tablet and preparation method thereof | 广州国标检验检测有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-117946050-A | Preparation method of ramelteon impurity dimer | 湖南慧泽生物医药科技有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-117756760-A | Synthesis method of 2, 3-dihydrobenzofuran | 山东邹平大展新材料有限公司 | 2024-03-26 | — | — | CN | disclosed |
| WO-2023198882-A1 | MELATONIN RECEPTOR AGONISTS FOR USE IN THE TREATMENT OF EPILEPSY DISORDERS | THERACULE AS (NO) | 2023-10-19 | — | — | WO | disclosed |
| CN-113045524-B | Synthesis method of ramelteon intermediate | 河南牧业经济学院 | 2023-09-22 | — | — | CN | disclosed |
| CN-115778925-A | Ramelteon oral dissolving film agent and preparation method thereof | 湖北广济医药科技有限公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-115477628-A | Synthesis method of ramelteon dimer | 江苏海悦康医药科技有限公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-110776485-B | Preparation method of ramelteon impurity | 山东邹平大展新材料有限公司 | 2022-09-30 | — | — | CN | disclosed |
| US-20220047608-A1 | Method of Treatment and Pharmaceutical Composition for Morning Hypertension | Dharma Laboratories LLC (US) | 2022-02-17 | — | — | US | disclosed |