Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 4/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22465929 | 1.00 | SNCA (0.38) | SNCATOP1TOP2ATOP2BHDAC3 | |
| SCHEMBL22465943 | 0.78 | BRD4 (0.40) | SNCATOP1TOP2ATOP2BHDAC3 | |
| SCHEMBL22465944 | 0.78 | BRD4 (0.40) | SNCATOP1TOP2ATOP2BHDAC3 | |
| SCHEMBL22466254 | 0.77 | RAB9A (0.41) | SNCAHDAC3MAPTLMNANPC1 | |
| SCHEMBL29377974 | 0.77 | RAB9A (0.41) | SNCAHDAC3MAPTLMNANPC1 | |
| SCHEMBL29378214 | 0.76 | TOP1 (0.41) | SNCATOP1TOP2ATOP2BHDAC3 | |
| SCHEMBL22465977 | 0.76 | TOP1 (0.41) | SNCATOP1TOP2ATOP2BHDAC3 | |
| SCHEMBL22466021 | 0.76 | BRD4 (0.38) | SNCATOP1TOP2ATOP2BMAPT | |
| SCHEMBL22466101 | 0.76 | BRD4 (0.38) | SNCATOP1TOP2ATOP2BMAPT | |
| SCHEMBL22465920 | 0.71 | P2RY1 (0.40) | MAPTLMNANPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3946599-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING | Neuropore Therapies, Inc. (US) | 2022-02-09 | — | — | EP | disclosed |