Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 2/20 | 1.00 |
| ▸ | TCF4 | P15884 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.74 |
| ▸ | POLB | P06746 | 3/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | PSMD14 | O00487 | 4/20 | 0.73 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.73 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.71 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.71 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.71 |
| ▸ | PTPN12 | Q05209 | 3/20 | 0.70 |
| ▸ | PTPN22 | Q9Y2R2 | 3/20 | 0.70 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.70 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | APAF1 | O14727 | 1/20 | 0.68 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12006900 | 1.00 | CTNNB1 (1.00) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL29373121 | 1.00 | CTNNB1 (1.00) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL25385999 | 1.00 | CTNNB1 (1.00) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL12006921 | 0.94 | CTNNB1 (0.88) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL12008462 | 0.93 | CTNNB1 (0.87) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL12008552 | 0.93 | CTNNB1 (0.87) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL13446890 | 0.93 | CTNNB1 (0.87) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL12008467 | 0.93 | CTNNB1 (0.86) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL12008732 | 0.92 | CTNNB1 (0.85) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL12006894 | 0.92 | CTNNB1 (0.85) | CTNNB1TCF4MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022031952-A9 | TREATMENTS FOR CANCERS HAVING KRAS MUTATIONS | CITY OF HOPE (US) | 2022-04-07 | — | — | WO | disclosed |
| WO-2022031952-A2 | TREATMENTS FOR CANCERS HAVING KRAS MUTATIONS | CITY OF HOPE (US) | 2022-02-10 | — | — | WO | disclosed |