Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 2/20 | 1.00 |
| ▸ | TCF4 | P15884 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.74 |
| ▸ | POLB | P06746 | 3/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | PSMD14 | O00487 | 4/20 | 0.73 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.73 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.71 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.71 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.71 |
| ▸ | PTPN12 | Q05209 | 3/20 | 0.70 |
| ▸ | PTPN22 | Q9Y2R2 | 3/20 | 0.70 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.70 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | APAF1 | O14727 | 1/20 | 0.68 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29373121 | 1.00 | CTNNB1 (1.00) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL25385999 | 1.00 | CTNNB1 (1.00) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL29382147 | 1.00 | CTNNB1 (1.00) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL12006921 | 0.94 | CTNNB1 (0.88) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL12008462 | 0.93 | CTNNB1 (0.87) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL12008552 | 0.93 | CTNNB1 (0.87) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL13446890 | 0.93 | CTNNB1 (0.87) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL12008467 | 0.93 | CTNNB1 (0.86) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL12008732 | 0.92 | CTNNB1 (0.85) | CTNNB1TCF4MEN1KMT2APOLB | |
| SCHEMBL12006894 | 0.92 | CTNNB1 (0.85) | CTNNB1TCF4MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10624949-B1 | Methods for treating diseases related to the wnt pathway | NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (US) | 2020-04-21 | — | — | US | claimed |
| CN-115627298-B | Molecular target for preparing product for diagnosing and treating honeybee microsporidiosis and application thereof | 中国农业科学院蜜蜂研究所 | 2023-03-10 | — | — | CN | disclosed |
| CN-115627298-A | Molecular target for preparing product for diagnosing and treating honeybee microsporidiosis and application thereof | 中国农业科学院蜜蜂研究所 | 2023-01-20 | — | — | CN | disclosed |
| US-10624949-B1 | Methods for treating diseases related to the wnt pathway | NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (US) | 2020-04-21 | — | — | US | disclosed |
| US-10273246-B2 | Methods and compositions of substituted 5H-[1,2,5] oxadiazolo [3′,4′:5,6] pyrazino[2,3-B] indole analogs as inhibitors of β-catenin/T-cell factor protein-protein interactions | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2019-04-30 | — | — | US | disclosed |
| US-20180134729-A1 | METHODS AND COMPOSITIONS OF SUBSTITUTED 5H-[1,2,5] OXADIAZOLO [3',4':5,6] PYRAZINO[2,3-B] INDOLE ANALOGS AS INHIBITORS OF BETA-CATENIN/T-CELL FACTOR PROTEIN-PROTEIN INTERACTIONS | UNIVERSITY OF UTAH | 2018-05-17 | — | — | US | disclosed |
| US-9738628-B2 | Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2017-08-22 | — | — | US | disclosed |
| US-9738628-B2 | Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2017-08-22 | — | — | US | disclosed |
| US-20170049751-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | DASGUPTA RAMANUJ (US) | 2017-02-23 | — | — | US | disclosed |
| US-20170049751-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | DASGUPTA RAMANUJ (US) | 2017-02-23 | — | — | US | disclosed |
| US-9173871-B2 | Oxazole and thiazole compounds as beta-catenin modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2015-11-03 | — | — | US | disclosed |
| US-20150025114-A1 | SUBSTITUTED 1H-INDAZOL-1-OL ANALOGS AS INHIBITORS OF BETA CATENIN/TCF PROTEIN-PROTEIN INTERACTIONS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2015-01-22 | — | — | US | disclosed |
| US-20150025114-A1 | SUBSTITUTED 1H-INDAZOL-1-OL ANALOGS AS INHIBITORS OF BETA CATENIN/TCF PROTEIN-PROTEIN INTERACTIONS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2015-01-22 | — | — | US | disclosed |
| WO-2013120045-A1 | SUBSTITUTED 1H-INDAZOL-1-OL ANALOGS AS INHIBITORS OF BETA CATENIN/TCF PROTEIN-PROTEIN INTERACTIONS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2013-08-15 | — | — | WO | disclosed |
| US-20130109675-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | NEW YORK UNIVERSITY | 2013-05-02 | — | — | US | disclosed |
| US-20120264744-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | UNITED STATES GOVERNMENT | 2012-10-18 | — | — | US | disclosed |
| US-8252823-B2 | Oxazole and thiazole compounds as beta-catenin modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252823-B2 | Oxazole and thiazole compounds as beta-catenin modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2012-08-28 | — | — | US | disclosed |
| US-20090227624-A1 | Oxazole and thiazole compounds as beta-catenin modulators and uses thereof | US ARMY, SECRETARY OF THE ARMY | 2009-09-10 | — | — | US | disclosed |
| US-20090227624-A1 | Oxazole and thiazole compounds as beta-catenin modulators and uses thereof | US ARMY, SECRETARY OF THE ARMY | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264744-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | CTNNB1, CTNNA1, CTNNBL1 | CTNNB1 1/4885TCF4 22/4885MEN1 3747/4885 |
| US-20090227624-A1 | Oxazole and thiazole compounds as beta-catenin modulators and uses thereof | CTNNB1, CTNNA1, CTNNBL1 | CTNNB1 1/4885TCF4 24/4885MEN1 4655/4885 |
| US-20180134729-A1 | METHODS AND COMPOSITIONS OF SUBSTITUTED 5H-[1,2,5] OXADIAZOLO [3',4':5,6] PYRAZINO[2,3-B] INDOLE ANALOGS AS INHIBITORS OF BETA-CATENIN/T-CELL FACTOR PROTEIN-PROTEIN INTERACTIONS | CTNNB1, CTNNBL1, WNT3A | CTNNB1 1/4885TCF4 24/4885MEN1 3834/4885 |
| US-20170049751-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | CTNNB1, CTNNA1, CTNNBL1 | CTNNB1 1/4885TCF4 24/4885MEN1 4655/4885 |
| US-20130109675-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | CTNNB1, CTNNA1, CTNNBL1 | CTNNB1 1/4885TCF4 24/4885MEN1 4655/4885 |
| US-20150025114-A1 | SUBSTITUTED 1H-INDAZOL-1-OL ANALOGS AS INHIBITORS OF BETA CATENIN/TCF PROTEIN-PROTEIN INTERACTIONS | CTNNB1, CTNNBL1, CTNNA1 | CTNNB1 1/4885TCF4 8/4885MEN1 3322/4885 |
| US-10273246-B2 | Methods and compositions of substituted 5H-[1,2,5] oxadiazolo [3′,4′:5,6] pyrazino[2,3-B] indole analogs as inhibitors of β-catenin/T-cell factor protein-protein interactions | CTNNB1, CTNNBL1, WNT3A | CTNNB1 1/4885TCF4 25/4885MEN1 3906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.