Trovafloxacin

Trovafloxacin

SCHEMBL29384064

N[C@@H]1[C@H]2CN(c3nc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3F)C[C@@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

gyrAgyrBparCparE

The experimentally established mechanism targets of Trovafloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHA2 P29317 1/20 1.00
FLT4 P35916 1/20 1.00
GSK3B P49841 1/20 1.00
RARB P10826 1/20 1.00
TBXAS1 P24557 1/20 1.00
SLC6A3 Q01959 1/20 1.00
LMNA P02545 4/20 0.90
KDM4E B2RXH2 3/20 0.90
ALDH1A1 P00352 3/20 0.90
HPGD P15428 2/20 0.90
HSD17B10 Q99714 2/20 0.90
POLB P06746 2/20 0.90
XBP1 P17861 1/20 0.90
NFKB1 P19838 1/20 0.90
HTT P42858 1/20 0.90
NFKB2 Q00653 1/20 0.90
RELA Q04206 1/20 0.90
KMT2A Q03164 2/20 0.77
DPP4 P27487 6/20 0.55
CYP2C9 P11712 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trovafloxacin SCHEMBL1902266 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL34465 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL20769811 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL13575805 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL34466 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL29688441 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL9177464 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL29711175 0.99 EPHA2 (0.98) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL1229029 0.99 EPHA2 (0.98) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL7688504 0.99 EPHA2 (0.98) EPHA2FLT4GSK3BRARBTBXAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4434588-B1 AEROSOL DELIVERY DEVICE PARI PHARMA GMBH (DE) 2026-04-08 EP claimed
EP-3452124-B1 HEMOSTATIC DEVICES AND METHODS OF USE MEDTRONIC INC (US) 2025-10-08 EP claimed
EP-3452123-B1 HEMOSTATIC DEVICES AND METHODS OF USE MEDTRONIC INC (US) 2025-09-24 EP claimed
EP-3965808-B1 USE OF PARASITES AND EXTRACELLULAR VESICLES OBTAINED FROM PARASITES IN CANCER TREATMENT UNIV YEDITEPE (TR) 2025-09-03 EP claimed
EP-4021402-B1 THIXOTROPIC DELIVERY SYSTEMS UNIV OF MONTANA (US) 2025-08-20 EP claimed
EP-3976197-B1 THERAPEUTICS AND METHODS FOR PREDICTING AND OVERCOMING ENDOCRINE RESISTANCE IN BREAST CANCER LUNELLA BIOTECH INC (CA) 2025-07-16 EP claimed
EP-3230500-B1 METHODS OF ORIENTING MULTIFILAMENT YARN AND MONOFILAMENTS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF TEPHA INC (US) 2025-06-18 EP claimed
EP-4554627-A1 INHALABLE FORMULATION FOR USE IN THE TREATMENT OF BACTERIAL LUNG INFECTIONS Solmic Biotech GmbH (DE) 2025-05-21 EP claimed
EP-3711797-B1 AEROSOL DELIVERY DEVICE PARI PHARMA GMBH (DE) 2025-02-12 EP claimed
CN-119317433-A Methods for treating cushing's syndrome and liver disease and reducing hepatotoxicity of other drugs taken by patients 科赛普特治疗学股份有限公司 2025-01-14 CN claimed
EP-3122757-B1 CHARGED LINKERS AND THEIR USES FOR CONJUGATION HANGZHOU DAC BIOTECH CO LTD (CN) 2023-09-06 EP claimed
EP-4232004-A1 FRACTAL FORMULATIONS Nanogyre Sprl (BE) 2023-08-30 EP claimed
EP-3452122-B1 HEMOSTATIC DEVICES AND METHODS OF USE MEDTRONIC INC (US) 2023-03-22 EP claimed
EP-3021832-B9 PRESERVED ETHERIFIED CYCLODEXTRIN DERIVATIVES CONTAINING LIQUID AQUEOUS PHARMACEUTICAL COMPOSITION BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2023-03-15 EP claimed
EP-3337456-B1 LIPOSOMES WITH GINSENOSIDE AS MEMBRANE MATERIAL AND PREPARATIONS AND USE THEREOF SHANGHAI GINPOSOME PHARMATECH CO LTD (CN) 2022-10-26 EP claimed
EP-2640393-B1 CBP/CATENIN ANTAGONISTS FOR ENHANCING ASYMMETRIC DIVISION OF SOMATIC STEM CELLS UNIV SOUTHERN CALIFORNIA (US) 2022-10-12 EP claimed
EP-3442984-B1 METHODS FOR DETECTING BORDETELLA QUEST DIAGNOSTICS INVEST LLC (US) 2022-08-10 EP claimed
EP-3265083-B1 SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE ST JUDE CHILDRENS RES HOSPITAL (US) 2022-07-06 EP claimed
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
EP-3067047-B1 LIPID-BASED COMPOSITIONS OF ANTIINFECTIVES FOR TREATING PULMONARY INFECTIONS INSMED INC (US) 2022-04-20 EP claimed