Trovafloxacin

Trovafloxacin

SCHEMBL34465

N[C@@H]1[C@H]2CN(c3nc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3F)C[C@@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

gyrAgyrBparCparE

The experimentally established mechanism targets of Trovafloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHA2 P29317 1/20 1.00
FLT4 P35916 1/20 1.00
GSK3B P49841 1/20 1.00
RARB P10826 1/20 1.00
TBXAS1 P24557 1/20 1.00
SLC6A3 Q01959 1/20 1.00
LMNA P02545 4/20 0.90
KDM4E B2RXH2 3/20 0.90
ALDH1A1 P00352 3/20 0.90
HPGD P15428 2/20 0.90
HSD17B10 Q99714 2/20 0.90
POLB P06746 2/20 0.90
XBP1 P17861 1/20 0.90
NFKB1 P19838 1/20 0.90
HTT P42858 1/20 0.90
NFKB2 Q00653 1/20 0.90
RELA Q04206 1/20 0.90
KMT2A Q03164 2/20 0.77
DPP4 P27487 6/20 0.55
CYP2C9 P11712 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trovafloxacin SCHEMBL1902266 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL20769811 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL13575805 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL34466 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL29384064 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL29688441 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL9177464 1.00 EPHA2 (1.00) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL29711175 0.99 EPHA2 (0.98) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL1229029 0.99 EPHA2 (0.98) EPHA2FLT4GSK3BRARBTBXAS1
Trovafloxacin SCHEMBL7688504 0.99 EPHA2 (0.98) EPHA2FLT4GSK3BRARBTBXAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 18968 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624057-B2 Bisphosphonate quinolone conjugates and uses thereof BIOVINC, LLC (US) 2026-05-12 US claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
EP-4724049-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF Catalent Ontario Limited (CA) 2026-04-15 EP claimed
EP-4434588-B1 AEROSOL DELIVERY DEVICE PARI PHARMA GMBH (DE) 2026-04-08 EP claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
US-20260027140-A1 COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA ATOPIC MEDICAL INC (US) 2026-01-29 US claimed
EP-4659014-A1 EMULSION-BASED THICK-FILM ANTIFOULING COATING FOR HIGHLY SENSITIVE ELECTROCHEMICAL SENSING President And Fellows Of Harvard College (US) 2025-12-10 EP claimed
US-12465623-B2 Use of parasites and extracellular vesicles obtained from parasites in cancer treatment YEDITEPE UNIVERSITESI (TR) 2025-11-11 US claimed
US-20250339551-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE DIFFERENT FUNCTIONAL SMALL MOLECULES FOR ENHANCED TREATMENT OF REFRACTORY DISEASES HANGZHOU SEEHE BIOTECHNOLOGY CO., LTD (CN) 2025-11-06 US claimed
EP-4642484-A1 TARGETED TREATMENT OF PROSTATE CANCERS AND OTHER TUMORS BY AN ANTIBODY-DRUG CONJUGATE Hangzhou Seehe Biotechnology Co., Ltd (CN) 2025-11-05 EP claimed
WO-1999000136-A1 CONTROL OF ACIDIC GUT SYNDROME THE UNIVERSITY OF NEW ENGLAND (AU) 1999-01-07 WO claimed
CN-1193977-A Polymorphs of the prodrug 6-N- (L-alanine-L-alanine) -trovafloxacin PFIZER (US) 1998-09-23 CN claimed
WO-1998036732-A2 COMBINATION PREPARATION FOR ORALLY ADMINISTERED ANTIBIOTICS LINDOPHARM GMBH (DE) 1998-08-27 WO claimed
CN-1190889-A Zwitterionic forms of trovafloxacin PFIZER (US) 1998-08-19 CN claimed
EP-0850060-A1 ZWITTERIONIC FORMS OF TROVAFLOXACIN PFIZER INC. (US) 1998-07-01 EP claimed
EP-0789697-B1 CRYSTAL FORM OF ANHYDROUS 7-((1a,5a, 6a)-6-AMINO-3-AZABICYCLO ( 3.1. 0]HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, METHANESULFONIC ACID SALT PFIZER (US) 1998-06-17 EP claimed
WO-1997008191-A1 POLYMORPHS OF THE PRODRUG 6-N-(L-ALA-L-ALA)-TROVAFLOXACIN PFIZER INC. (US) 1997-03-06 WO claimed
WO-1997007800-A1 ZWITTERIONIC FORMS OF TROVAFLOXACIN PFIZER INC. (US) 1997-03-06 WO claimed
US-5164402-A Bactericides PFIZER INC (US) 1992-11-17 US claimed
WO-1991002526-A1 AZABICYCLO QUINOLONE CARBOXYLIC ACIDS PFIZER INC. (US) 1991-03-07 WO claimed