Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13085702 | 1.00 | KDM1A (0.56) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL17807330 | 0.91 | NOTUM (0.64) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL30413026 | 0.85 | NOTUM (0.53) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL15676941 | 0.85 | NOTUM (0.53) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL30898670 | 0.85 | NOTUM (0.53) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL25350959 | 0.85 | NOTUM (0.53) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL1222469 | 0.85 | NOTUM (0.53) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL5578612 | 0.85 | HDAC1 (0.55) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL25229656 | 0.85 | NOTUM (0.51) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| Hydrochloric Acid SCHEMBL25232027 | 0.84 | NOTUM (0.52) | KDM1ANOTUMHDAC1HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113330008-B | Preparation method of amide compound and application of amide compound in medicine field | 上海华汇拓医药科技有限公司 | 2024-05-07 | — | — | CN | disclosed |
| EP-4192957-A2 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| CN-116113698-A | TRPML modulators | 卡斯玛治疗公司 | 2023-05-12 | — | — | CN | disclosed |
| WO-2022032073-A2 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2022-02-10 | — | — | WO | disclosed |