Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29384374 | 1.00 | KDM1A (0.56) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL17807330 | 0.91 | NOTUM (0.64) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL30413026 | 0.85 | NOTUM (0.53) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL15676941 | 0.85 | NOTUM (0.53) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL30898670 | 0.85 | NOTUM (0.53) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL25350959 | 0.85 | NOTUM (0.53) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL1222469 | 0.85 | NOTUM (0.53) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL5578612 | 0.85 | HDAC1 (0.55) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL25229656 | 0.85 | NOTUM (0.51) | KDM1ANOTUMHDAC1HDAC6HDAC8 | |
| Hydrochloric Acid SCHEMBL25232027 | 0.84 | NOTUM (0.52) | KDM1ANOTUMHDAC1HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-12-28 | — | — | US | disclosed |
| EP-4192957-A2 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| WO-2022032073-A2 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2022-02-10 | — | — | WO | disclosed |
| US-8729264-B2 | Agent for prevention and/or treatment of skin diseases | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-05-20 | — | — | US | disclosed |
| US-8729264-B2 | Agent for prevention and/or treatment of skin diseases | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-05-20 | — | — | US | disclosed |
| US-20100256134-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | KDM1A 3127/4885NOTUM 2050/4885HDAC1 2067/4885 |
| US-20100256134-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | TYR, CUTA, SERPINB1 | KDM1A 1362/4885NOTUM 537/4885HDAC1 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.