Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.61 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | BLM | P54132 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nortopixantrone SCHEMBL7804438 | 1.00 | TOP2A (0.61) | TOP2ATOP2BECE1MUS81TP53 | |
| Nortopixantrone SCHEMBL29711469 | 0.99 | TOP2A (0.60) | TOP2ATOP2BECE1MUS81TP53 | |
| SCHEMBL7810460 | 0.96 | TOP2A (0.61) | TOP2ATOP2BECE1MUS81TP53 | |
| SCHEMBL7811993 | 0.96 | TOP2A (0.61) | TOP2ATOP2BECE1MUS81TP53 | |
| SCHEMBL7810474 | 0.94 | TOP2A (0.68) | TOP2ATOP2BECE1MUS81TP53 | |
| SCHEMBL7804826 | 0.93 | TOP2A (0.61) | TOP2ATOP2BECE1MUS81TP53 | |
| SCHEMBL7811757 | 0.92 | TOP2A (0.48) | TOP2ATOP2BECE1MUS81TP53 | |
| SCHEMBL7804428 | 0.91 | TOP2A (0.68) | TOP2ATOP2BECE1MUS81TP53 | |
| SCHEMBL7804649 | 0.90 | TOP2A (0.60) | TOP2ATOP2BECE1MUS81TP53 | |
| SCHEMBL7812099 | 0.90 | TOP2A (0.60) | TOP2ATOP2BECE1MUS81TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025096952-A1 | SCAFFOLDS AND SCAFFOLD HOLDERS FOR TISSUE ENGINEERING | UNIVERSITY OF CONNECTICUT (US) | 2025-05-08 | — | — | WO | disclosed |
| US-11607458-B2 | Enrichment-triggered chemical delivery system | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2023-03-21 | — | — | US | disclosed |
| US-20220047505-A1 | Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration | STI PHARMA, LLC (US) | 2022-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11607458-B2 | Enrichment-triggered chemical delivery system | HMGB1, PAICS, CCL2 | TOP2A 1182/4885TOP2B 1142/4885ECE1 776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.