Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.48 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | BLM | P54132 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7804806 | 0.96 | TOP2A (0.48) | TOP2AECE1MUS81MAPTBLM | |
| SCHEMBL7810430 | 0.93 | TOP2A (0.45) | TOP2AECE1MUS81MAPTBLM | |
| SCHEMBL7814890 | 0.93 | ECE1 (0.48) | TOP2AECE1MUS81MAPTBLM | |
| SCHEMBL7804859 | 0.93 | TOP2A (0.44) | TOP2AECE1MUS81MAPTBLM | |
| SCHEMBL7804823 | 0.92 | TOP2A (0.44) | TOP2AECE1MUS81MAPTBLM | |
| SCHEMBL7810460 | 0.92 | TOP2A (0.61) | TOP2AECE1MUS81MAPTBLM | |
| Nortopixantrone SCHEMBL29385196 | 0.92 | TOP2A (0.61) | TOP2AECE1MUS81MAPTBLM | |
| Nortopixantrone SCHEMBL7804438 | 0.92 | TOP2A (0.61) | TOP2AECE1MUS81MAPTBLM | |
| SCHEMBL7808820 | 0.91 | TOP2A (0.43) | TOP2AECE1MUS81 | |
| Nortopixantrone SCHEMBL29711469 | 0.91 | TOP2A (0.60) | TOP2AECE1MUS81MAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662076-B1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | UNIV VERMONT (US) | 2001-04-11 | — | — | EP | disclosed |
| US-5604246-A | HAVING POTENCY AGAINST MULTIDRUG RESISTANT TUMORS | BOEHRINGER MANNHEIM ITALIA SPA (IT) | 1997-02-18 | — | — | US | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| US-5519029-A | ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1996-05-21 | — | — | US | disclosed |