SCHEMBL29385342

SCHEMBL29385342

CNc1nc(N)c2[nH]cnc2n1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.59
GDA Q9Y2T3 1/20 0.59
POLA1 P09884 2/20 0.54
CDK2 P24941 6/20 0.48
CDK1 P06493 5/20 0.48
CCNB1 P14635 5/20 0.48
CCNA2 P20248 5/20 0.48
CCNA1 P78396 5/20 0.48
CCNB2 O95067 1/20 0.48
CCNB3 Q8WWL7 1/20 0.48
XDH P47989 2/20 0.47
PI4KA P42356 2/20 0.47
PI4K2B Q8TCG2 2/20 0.47
PI4K2A Q9BTU6 2/20 0.47
PI4KB Q9UBF8 2/20 0.47
LMNA P02545 1/20 0.47
DRD3 P35462 1/20 0.47
LRRK2 Q5S007 1/20 0.47
MAP3K5 Q99683 1/20 0.44
DPP4 P27487 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9119 1.00 PDPK1 (0.59) PDPK1GDAPOLA1CDK2CDK1
SCHEMBL14977062 0.84 PDPK1 (0.61) PDPK1GDAPOLA1CDK2CDK1
SCHEMBL28274636 0.83 PDPK1 (0.56) PDPK1GDAPOLA1CDK2CDK1
SCHEMBL16145922 0.81 POLA1 (0.55) PDPK1GDAPOLA1CDK2CDK1
SCHEMBL11876697 0.80 XDH (0.67) CDK2CDK1CCNB1CCNA2CCNA1
SCHEMBL14938904 0.79 GDA (0.54) PDPK1GDAPOLA1XDHPI4KA
SCHEMBL16146953 0.79 POLA1 (0.56) PDPK1GDAPOLA1CDK2CDK1
SCHEMBL2730455 0.79 PDPK1 (0.56) PDPK1GDAPOLA1CDK2CDK1
SCHEMBL377763 0.79 CDK2 (0.48) PDPK1GDACDK2CDK1CCNB1
SCHEMBL28387743 0.78 PDPK1 (0.54) PDPK1GDAPOLA1CDK2CDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3419665-B1 TREATMENT METHODS FOR FIBROSIS TARGETING SMOC2 BRIGHAM & WOMENS HOSPITAL INC (US) 2024-10-30 EP claimed
EP-3843845-B1 INHIBITION OF PROTEIN KINASES TO TREAT FRIEDREICH ATAXIA UNIV MASSACHUSETTS (US) 2026-03-11 EP disclosed
EP-4705462-A2 COMPOSITIONS AND METHODS FOR ENGINEERING MATURE IPSC-DERIVED AND ESC-DERIVED HEPATOCYTES Duke University (US) 2026-03-11 EP disclosed
EP-4685144-A1 NON-FLUORESCENT COMPOUND AND USES THEREOF SFC Co., Ltd. (KR) 2026-01-28 EP disclosed
US-20260015655-A1 COMPOUNDS AND THEIR APPLICATIONS SFC CO., LTD. (KR) 2026-01-15 US disclosed
EP-4674845-A1 NOVEL COMPOUND AND USE THEREOF SFC Co., Ltd. (KR) 2026-01-07 EP disclosed
EP-4649147-A2 TYPE II CAS PROTEINS AND APPLICATIONS THEREOF Alia Therapeutics Srl (IT) 2025-11-19 EP disclosed
EP-3368089-B1 NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACID COMPLEXES TRANSLATE BIO MA INC (US) 2025-11-05 EP disclosed
EP-4637842-A1 INHIBITION OF ZBTB7A Icahn School of Medicine at Mount Sinai (US) 2025-10-29 EP disclosed
EP-4630557-A1 INHIBITORY NUCLEIC ACIDS AND METHODS OF USE THEREOF The Regents of the University of California (US) 2025-10-15 EP disclosed
WO-2022081693-A1 COMPOSITIONS AND METHODS TARGETING CIRC2082 FOR THE TREATMENT OF CANCER THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2022-04-21 WO disclosed
CN-114375300-A Universal donor cell 克里斯珀医疗股份公司 2022-04-19 CN disclosed
CN-114375194-A Treatment of angiopoietin-like 7(ANGPTL7) -related diseases 艾姆皮瑞克公司 2022-04-19 CN disclosed
CN-114364791-A Universal donor cell 克里斯珀医疗股份公司 2022-04-15 CN disclosed
WO-2022076901-A1 NOVEL TARGETS FOR REACTIVATION OF PRADER-WILLI SYNDROME-ASSOCIATED GENES DUKE UNIVERSITY (US) 2022-04-14 WO disclosed
WO-2022070107-A1 MATERIALS AND METHODS FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CRISPR THERAPEUTICS AG (CH) 2022-04-07 WO disclosed
EP-3976594-A1 A THERAPEUTIC APPROACH FOR TREATING NON-INFECTIOUS OCULAR IMMUNOINFLAMMATORY DISORDERS The Schepens Eye Research Institute, Inc. (US) 2022-04-06 EP disclosed
CN-107530399-B Effective delivery of therapeutic molecules in vitro and in vivo 马萨诸塞眼科耳科诊所 2022-03-18 CN disclosed
CN-114206849-A Therapeutic methods for treating non-infectious ocular immunoinflammatory disorders 斯格本斯眼科研究所有限公司 2022-03-18 CN disclosed
EP-3946629-A1 THERAPEUTIC TARGETS FOR ONCOGENIC KRAS-DEPENDENT CANCERS University Of Massachusetts (US) 2022-02-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260015655-A1 COMPOUNDS AND THEIR APPLICATIONS OGA, NSUN3, CDK10 PDPK1 4063/4885GDA 3900/4885POLA1 2880/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.