Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 20/20 | 0.75 |
| ▸ | PLK1 | P53350 | 5/20 | 0.75 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.75 |
| ▸ | GAK | O14976 | 1/20 | 0.75 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.75 |
| ▸ | JAK2 | O60674 | 1/20 | 0.75 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.75 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.75 |
| ▸ | PAK4 | O96013 | 1/20 | 0.75 |
| ▸ | ABL1 | P00519 | 1/20 | 0.75 |
| ▸ | LCK | P06239 | 1/20 | 0.75 |
| ▸ | FYN | P06241 | 1/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | WEE2 | P0C1S8 | 1/20 | 0.75 |
| ▸ | BCR | P11274 | 1/20 | 0.75 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.75 |
| ▸ | SYK | P43405 | 1/20 | 0.75 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.75 |
| ▸ | NEK2 | P51955 | 1/20 | 0.75 |
| ▸ | NEK3 | P51956 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21815225 | 1.00 | WEE1 (0.75) | WEE1PLK1CRBNGAKEPHB6 | |
| SCHEMBL26134750 | 1.00 | WEE1 (0.75) | WEE1PLK1CRBNGAKEPHB6 | |
| SCHEMBL26120792 | 1.00 | WEE1 (0.75) | WEE1PLK1CRBNGAKEPHB6 | |
| SCHEMBL26114799 | 0.95 | WEE1 (0.72) | WEE1PLK1CRBNGAKEPHB6 | |
| SCHEMBL26111908 | 0.95 | WEE1 (0.72) | WEE1PLK1CRBNGAKEPHB6 | |
| SCHEMBL26135045 | 0.95 | WEE1 (0.72) | WEE1PLK1CRBNGAKEPHB6 | |
| SCHEMBL26135527 | 0.95 | WEE1 (0.79) | WEE1PLK1CRBNGAKEPHB6 | |
| SCHEMBL26134993 | 0.95 | WEE1 (0.71) | WEE1PLK1CRBNGAKEPHB6 | |
| SCHEMBL26118428 | 0.94 | WEE1 (0.72) | WEE1PLK1CRBNGAKEPHB6 | |
| SCHEMBL26115864 | 0.93 | WEE1 (0.73) | WEE1PLK1CRBNGAKEPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12318452-B2 | Degraders of WEE1 kinase | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2025-06-03 | — | — | US | disclosed |
| US-20220047709-A1 | DEGRADERS OF WEE1 KINASE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220047709-A1 | DEGRADERS OF WEE1 KINASE | WEE1, WEE2, PPME1 | WEE1 1/4885PLK1 11/4885CRBN 553/4885 |
| US-12318452-B2 | Degraders of WEE1 kinase | WEE1, WEE2, PPME1 | WEE1 1/4885PLK1 11/4885CRBN 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.