Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alosetron. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A known ✓ | P46098 | 3/20 | 0.98 |
| ▸ | CASP6 | P55212 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.98 |
| ▸ | HTR2A | P28223 | 1/20 | 0.98 |
| ▸ | HTR2C | P28335 | 1/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.98 |
| ▸ | CD44 | P16070 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.40 |
| ▸ | HTR3B | O95264 | 2/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alosetron SCHEMBL806 | 1.00 | CASP6 (1.00) | CASP6KCNH2HTR3ACYP3A4CYP1A2 | |
| Alosetron SCHEMBL29377019 | 0.99 | KCNH2 (1.00) | CASP6KCNH2HTR3ACYP3A4CYP1A2 | |
| Alosetron SCHEMBL631 | 0.99 | KCNH2 (1.00) | CASP6KCNH2HTR3ACYP3A4CYP1A2 | |
| Alosetron SCHEMBL635233 | 0.97 | KCNH2 (0.96) | CASP6KCNH2HTR3ACYP3A4CYP1A2 | |
| Alosetron SCHEMBL850 | 0.94 | KCNH2 (0.90) | CASP6KCNH2HTR3ACYP3A4CYP1A2 | |
| SCHEMBL837 | 0.93 | KCNH2 (0.88) | CASP6KCNH2HTR3ACYP3A4CYP1A2 | |
| Alosetron SCHEMBL13345838 | 0.92 | KCNH2 (0.86) | CASP6KCNH2HTR3ACYP3A4CYP1A2 | |
| Alosetron SCHEMBL1046 | 0.92 | KCNH2 (0.85) | CASP6KCNH2HTR3ACYP3A4CYP1A2 | |
| Alosetron SCHEMBL1045 | 0.92 | KCNH2 (0.85) | CASP6KCNH2HTR3ACYP3A4CYP1A2 | |
| Alosetron SCHEMBL13345845 | 0.89 | KCNH2 (0.81) | CASP6KCNH2HTR3ACYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| EP-3802850-B1 | DEVICES AND SYSTEMS FOR GASTROINTESTINAL MICROBIOME DETECTION AND MANIPULATION | BT BIDCO INC (US) | 2025-11-19 | — | — | EP | disclosed |
| US-20240145031-A1 | Methods and devices for drug repositioning and drug repurposing as nuclear receptor modulators | Precision Medicine Lab (NL) | 2024-05-02 | — | — | US | disclosed |
| US-11246873-B2 | Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-02-15 | — | — | US | disclosed |