Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 1.00 |
| ▸ | PDE5A | O76074 | 5/20 | 1.00 |
| ▸ | RAD52 | P43351 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | UBE2N | P61088 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | GBA1 | P04062 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | BCHE | P06276 | 4/20 | 0.63 |
| ▸ | ACHE | P22303 | 4/20 | 0.63 |
| ▸ | GALR3 | O60755 | 2/20 | 0.59 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3113122 | 1.00 | APP (1.00) | APPPDE5ARAD52KMT2ALMNA | |
| SCHEMBL3106597 | 0.92 | APP (0.85) | APPPDE5ARAD52KMT2ALMNA | |
| SCHEMBL3782735 | 0.90 | APP (0.81) | APPPDE5ARAD52KMT2ALMNA | |
| SCHEMBL3121152 | 0.90 | APP (0.81) | APPPDE5ARAD52KMT2ALMNA | |
| SCHEMBL3113251 | 0.90 | APP (0.81) | APPPDE5ARAD52KMT2ALMNA | |
| SCHEMBL3108304 | 0.87 | APP (0.76) | APPPDE5ARAD52KMT2ALMNA | |
| SCHEMBL21055802 | 0.86 | PDE5A (0.76) | APPPDE5ARAD52KMT2ALMNA | |
| SCHEMBL3638414 | 0.86 | APP (0.74) | APPPDE5ARAD52KMT2ALMNA | |
| SCHEMBL2262120 | 0.86 | APP (0.74) | APPPDE5ARAD52KMT2ALMNA | |
| SCHEMBL1685041 | 0.86 | APP (0.74) | APPPDE5ALMNAALDH1A1NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036063-A2 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATIVE DISEASES | THE BROAD INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |