Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2191034 | 0.97 | — | — | |
| SCHEMBL5839398 | 0.97 | — | — | |
| Bromide SCHEMBL819575 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL290926 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL9278274 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL6013686 | 0.94 | — | — | |
| SCHEMBL10381944 | 0.94 | — | — | |
| SCHEMBL61348 | 0.94 | — | — | |
| SCHEMBL648363 | 0.94 | — | — | |
| Bromide SCHEMBL10574091 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022148459-A1 | CLASS OF NOVEL SMAD3 PROTEIN DEGRADERS AND APPLICATION THEREOF | 和径医药科技（上海）有限公司 | 2022-07-14 | — | — | WO | disclosed |
| US-20100069598-A1 | RING-OPENING POLYMERIZATION OF CYCLIC ESTERS, POLYESTERS FORMED THEREBY, AND ARTICLES COMPRISING THE POLYESTERS | NATIONAL SCIENCE FOUNDATION | 2010-03-18 | — | — | US | disclosed |
| US-7671140-B2 | Ring-opening polymerization of cyclic esters, polyesters formed thereby, and articles comprising the polyesters | THE UNIVERSITY OF CONNECTICUT (US) | 2010-03-02 | — | — | US | disclosed |
| WO-2008124035-A2 | RING-OPENING POLYMERIZATION OF CYCLIC ESTERS, POLYESTERS FORMED THEREBY, AND ARTICLES COMPRISING THE POLYESTERS | UNIVERSITY OF CONNECTICUT (US) | 2008-10-16 | — | — | WO | disclosed |
| US-20080249255-A1 | RING-OPENING POLYMERIZATION OF CYCLIC ESTERS, POLYESTERS FORMED THEREBY, AND ARTICLES COMPRISING THE POLYESTERS | NATIONAL SCIENCE FOUNDATION | 2008-10-09 | — | — | US | disclosed |
| US-20040018598-A1 | Bio-intermediates for use in the chemical synthesis of polyketides | SANTI DANIEL (US) | 2004-01-29 | — | — | US | disclosed |
| EP-1307579-A2 | BIO-INTERMEDIATES FOR USE IN THE CHEMICAL SYNTHESIS OF POLYKETIDES | Kosan Biosciences, Inc. (US) | 2003-05-07 | — | — | EP | disclosed |
| US-20020052028-A1 | Bio-intermediates for use in the chemical synthesis of polyketides | KOSAN BIOSCIENCES, INC. | 2002-05-02 | — | — | US | disclosed |
| WO-2002012534-A2 | BIO-INTERMEDIATES FOR USE IN THE CHEMICAL SYNTHESIS OF POLYKETIDES | KOSAN BIOSCIENCES, INC. (US) | 2002-02-14 | — | — | WO | disclosed |