Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 6/20 | 0.50 |
| ▸ | PARP6 | Q2NL67 | 5/20 | 0.50 |
| ▸ | PARP3 | Q9Y6F1 | 4/20 | 0.50 |
| ▸ | TNKS | O95271 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
| ▸ | CBFB | Q13951 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24282029 | 1.00 | PARP1 (0.50) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL22912817 | 0.89 | KDM4E (0.57) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL29396642 | 0.89 | KDM4E (0.57) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL28686826 | 0.86 | PARP1 (0.48) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL29397055 | 0.86 | PARP1 (0.48) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL30493593 | 0.79 | MAPT (0.48) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL25321380 | 0.79 | MAPT (0.48) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL15745613 | 0.79 | CBFB (0.48) | PARP1PARP2PARP6PARP3MEN1 | |
| SCHEMBL22912784 | 0.78 | PARP1 (0.52) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL29396356 | 0.78 | PARP1 (0.52) | PARP1PARP2PARP6PARP3TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116348115-B | Combination of antibody-drug conjugate and PARP1 selective inhibitor | ASTRAZENECA UK LTD. (GB) | 2026-05-26 | — | — | CN | disclosed |
| EP-3999506-B1 | PARP1 INHIBITORS | ASTRAZENECA AB (SE) | 2025-01-15 | — | — | EP | disclosed |
| CN-114144413-B | PARP1 inhibitors | 阿斯利康(瑞典)有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-116425744-A | Piperazine-containing ring derivative, pharmaceutically acceptable salt thereof, and preparation method and application thereof | 优领医药科技(香港)有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-116348115-A | Combination of antibody-drug conjugate and PARP1 selective inhibitor | 阿斯利康(英国)有限公司 | 2023-06-27 | — | — | CN | disclosed |
| EP-3999506-A1 | PARP1 INHIBITORS | Astrazeneca AB (SE) | 2022-05-25 | — | — | EP | disclosed |
| CN-114144413-A | PARP1 inhibitors | 阿斯利康(瑞典)有限公司 | 2022-03-04 | — | — | CN | disclosed |