Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3751510 | 1.00 | BRAF (0.43) | BRAFKDRFLT1PIK3CDABL1 | |
| SCHEMBL28686068 | 0.89 | KDR (0.38) | BRAFKDRFLT1PIK3CDABL1 | |
| SCHEMBL9909777 | 0.87 | BRAF (0.41) | BRAFKDRFLT1 | |
| SCHEMBL29396856 | 0.87 | BRAF (0.41) | BRAFKDRFLT1 | |
| SCHEMBL28690805 | 0.86 | KDR (0.41) | BRAFKDRFLT1PIK3CDABL1 | |
| SCHEMBL2931209 | 0.86 | BRAF (0.44) | BRAFKDREGFR | |
| SCHEMBL29837321 | 0.85 | KDR (0.49) | BRAFKDRFLT1 | |
| SCHEMBL29837320 | 0.85 | KDR (0.49) | BRAFKDRFLT1 | |
| SCHEMBL28706557 | 0.85 | ABL1 (0.47) | BRAFKDRFLT1PIK3CDABL1 | |
| SCHEMBL28690910 | 0.85 | KDR (0.42) | BRAFKDRFLT1ABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999057-A1 | POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES | ANAGENESIS BIOTECHNOLOGIES SAS (FR) | 2022-05-25 | — | — | EP | disclosed |
| CN-114144410-A | Polyarylurea derivatives and their use in the treatment of muscular diseases | 阿纳格纳斯生物技术股份有限公司 | 2022-03-04 | — | — | CN | disclosed |