Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29397182 | 0.86 | BRAF (0.43) | BRAFEGFRKDR | |
| SCHEMBL3751510 | 0.86 | BRAF (0.43) | BRAFEGFRKDR | |
| SCHEMBL2926569 | 0.82 | KDR (0.47) | BRAFKDRKITPDGFRAFGFR2 | |
| SCHEMBL2933076 | 0.80 | BRAF (0.71) | BRAF | |
| SCHEMBL2935339 | 0.79 | PDGFRB (0.34) | BRAFEGFRBTKKDRPDGFRA | |
| SCHEMBL28698618 | 0.78 | BRAF (0.68) | BRAF | |
| SCHEMBL2928277 | 0.78 | BRAF (0.73) | BRAFKDRKITPDGFRA | |
| SCHEMBL2937387 | 0.77 | BRAF (0.69) | BRAF | |
| SCHEMBL2928213 | 0.76 | PDGFRA (0.44) | BRAFEGFRBTKKDRKIT | |
| SCHEMBL3759308 | 0.76 | AURKA (0.35) | BRAFEGFRBTKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |