Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22470597 | 1.00 | NR4A2 (0.44) | NR4A2PARP1OPRK1CD38MEN1 | |
| SCHEMBL22443320 | 0.82 | NR4A2 (0.44) | NR4A2PARP1ALDH1A1MAPTHPGD | |
| SCHEMBL15808776 | 0.82 | PARP1 (0.42) | PARP1CD38ALDH1A1MAPTHPGD | |
| SCHEMBL31363646 | 0.82 | PARP1 (0.39) | NR4A2PARP1CD38AXLMAP2K1 | |
| SCHEMBL18225293 | 0.82 | NR4A2 (0.48) | NR4A2 | |
| SCHEMBL5156191 | 0.81 | DHODH (0.47) | PARP1MEN1ALDH1A1PRNPMAPT | |
| SCHEMBL12999419 | 0.77 | CYP3A4 (0.46) | OPRK1MEN1ALDH1A1MAPTHTT | |
| SCHEMBL25395312 | 0.76 | NR4A2 (0.41) | NR4A2OPRK1ALDH1A1HTTMAP2K1 | |
| SCHEMBL30618047 | 0.76 | NR4A2 (0.41) | NR4A2OPRK1ALDH1A1MAPT | |
| SCHEMBL30591117 | 0.76 | NR4A2 (0.41) | NR4A2OPRK1ALDH1A1HTTMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669744-A | Nrf2 activating compounds | 千寿制药株式会社 | 2023-08-29 | — | — | CN | disclosed |
| WO-2023151640-A1 | HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | BEIGENE , LTD. (KY) | 2023-08-17 | — | — | WO | disclosed |
| WO-2022145459-A1 | NRF2-ACTIVATING COMPOUND | 千寿製薬株式会社 | 2022-07-07 | — | — | WO | disclosed |
| CN-114080389-A | Nrf2 activating compound | 千寿制药株式会社 | 2022-02-22 | — | — | CN | disclosed |