Lamtidine

Lamtidine

SCHEMBL29398554

Cn1nc(N)nc1NCCCOc1cccc(CN2CCCCC2)c1

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH2 P25021 4/20 0.61
SMN1; SMN2 Q16637 2/20 0.57
TP53 P04637 1/20 0.57
CYP1A2 P05177 1/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2D6 P10635 1/20 0.57
TSHR P16473 1/20 0.57
MAPK1 P28482 1/20 0.57
THPO P40225 1/20 0.57
MTOR P42345 1/20 0.57
RAB9A P51151 1/20 0.57
HIF1A Q16665 1/20 0.57
HRH3 Q9Y5N1 1/20 0.52
MEN1 O00255 1/20 0.50
GMNN O75496 1/20 0.50
ALDH1A1 P00352 1/20 0.50
LMNA P02545 1/20 0.50
MAPT P10636 1/20 0.50
PMP22 Q01453 1/20 0.50
KMT2A Q03164 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lamtidine SCHEMBL534965 1.00 HRH2 (0.61) HRH2SMN1; SMN2TP53CYP1A2CYP3A4
SCHEMBL11296591 1.00 HRH2 (0.61) HRH2SMN1; SMN2TP53CYP1A2CYP3A4
SCHEMBL11093446 0.96 HRH2 (0.56) HRH2SMN1; SMN2TP53CYP1A2CYP3A4
SCHEMBL11098343 0.96 HRH2 (0.56) HRH2SMN1; SMN2TP53CYP1A2CYP3A4
SCHEMBL10750433 0.89 HRH2 (0.56) HRH2SMN1; SMN2TP53CYP1A2CYP3A4
SCHEMBL11011262 0.88 SMN1; SMN2 (0.57) HRH2SMN1; SMN2TP53CYP1A2CYP3A4
Roxatidine Acetate SCHEMBL9545521 0.88 HRH2 (0.74) HRH2HRH3
SCHEMBL11100561 0.88 HRH3 (0.55) TSHRHRH3
SCHEMBL10750980 0.88 SMN1; SMN2 (0.54) HRH2SMN1; SMN2TP53CYP1A2CYP3A4
Lavoltidine SCHEMBL1142 0.87 SMN1; SMN2 (0.55) HRH2SMN1; SMN2TP53CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230349922-A1 H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer UNIVERSITÉ DE STRASBOURG (FR) 2023-11-02 US disclosed
EP-4196793-A1 H2 BLOCKERS TARGETING LIVER MACROPHAGES FOR THE PREVENTION AND TREATMENT OF LIVER DISEASE AND CANCER Université de Strasbourg (FR) 2023-06-21 EP disclosed
WO-2022124243-A1 TIMED-ELUTION MASKING PARTICLES AND ORAL PHARMACEUTICAL COMPOSITION CONTAINING SAME 東和薬品株式会社 2022-06-16 WO disclosed
WO-2022034121-A1 H2 BLOCKERS TARGETING LIVER MACROPHAGES FOR THE PREVENTION AND TREATMENT OF LIVER DISEASE AND CANCER UNIVERSITÉ DE STRASBOURG (FR) 2022-02-17 WO disclosed