Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.66 |
| ▸ | CAMK2A | Q9UQM7 | 3/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.46 |
| ▸ | CLIC1 | O00299 | 1/20 | 0.46 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 2/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.43 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030956 | 1.00 | PTGS2 (0.66) | PTGS2CAMK2AABCB11PTGS1NR1I3 | |
| SCHEMBL1028714 | 0.88 | PTGS2 (0.54) | PTGS2CAMK2AABCB11PTGS1NR1I3 | |
| SCHEMBL1032830 | 0.88 | PTGS2 (0.54) | PTGS2CAMK2AABCB11PTGS1NR1I3 | |
| SCHEMBL6036173 | 0.88 | PTGS2 (0.52) | PTGS2CAMK2AABCB11PTGS1NR1I3 | |
| SCHEMBL1032831 | 0.87 | PTGS2 (0.61) | PTGS2CAMK2AABCB11PTGS1NR1I3 | |
| SCHEMBL2070703 | 0.86 | PTGS2 (0.88) | PTGS2CAMK2AABCB11PTGS1NR1I3 | |
| SCHEMBL1031824 | 0.86 | PTGS2 (0.76) | PTGS2CAMK2AABCB11PTGS1NR1I3 | |
| SCHEMBL6036623 | 0.83 | PTGS2 (0.72) | PTGS2CAMK2AABCB11PTGS1NR1I3 | |
| SCHEMBL27752715 | 0.81 | PTGS2 (0.55) | PTGS2CAMK2AABCB11PTGS1NR1I3 | |
| SCHEMBL1032030 | 0.80 | PTGS2 (0.56) | PTGS2CAMK2AABCB11PTGS1NR1I3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956025-A1 | CGRP ANTAGONISTS FOR THE TREATMENT OF MEDICATION OVERUSE HEADACHE, POST-TRAUMATIC HEADACHE, POST-CONCUSSION SYNDROME AND VERTIGO | Allergan Sales, LLC (US) | 2022-02-23 | — | — | EP | claimed |
| EP-4263571-A1 | COMPOSITIONS FOR IMPROVED DELIVERY OF CGRP INHIBITORS | Pfizer Ireland Pharmaceuticals (IE) | 2023-10-25 | — | — | EP | disclosed |
| EP-4247364-A1 | COMPOSITIONS FOR IMPROVED DELIVERY OF CGRP INHIBITORS | Pfizer Ireland Pharmaceuticals (IE) | 2023-09-27 | — | — | EP | disclosed |
| CN-116456981-A | Compositions for improved GRP inhibitor delivery | 辉瑞爱尔兰制药公司 | 2023-07-18 | — | — | CN | disclosed |
| EP-4076395-A1 | INTRANASAL PHARMACEUTICAL COMPOSITIONS OF CGRP INHIBITORS | Biohaven Pharmaceutical Holding Company Ltd. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-114980862-A | Intranasal pharmaceutical compositions of CGRP inhibitors | 拜尔哈文制药股份有限公司 | 2022-08-30 | — | — | CN | disclosed |
| WO-2022165291-A1 | PHARMACEUTICAL COMPOSITIONS OF CGRP INHIBITORS AND METHODS OF THEIR USE | BIOHAVEN PHARMACEUTICAL HOLDING COMPANY LTD. (US) | 2022-08-04 | — | — | WO | disclosed |
| EP-4034156-A1 | COMBINATION THERAPY WITH CGRP ANTAGONISTS | Allergan Pharmaceuticals International Limited (IE) | 2022-08-03 | — | — | EP | disclosed |
| WO-2022132989-A1 | COMPOSITIONS FOR IMPROVED DELIVERY OF CGRP INHIBITORS | BIOHAVEN PHARMACEUTICAL HOLDING COMPANY LTD. (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022109077-A1 | COMPOSITIONS FOR IMPROVED DELIVERY OF CGRP INHIBITORS | BIOHAVEN PHARMACEUTICAL HOLDING COMPANY LTD. (US) | 2022-05-27 | — | — | WO | disclosed |
| EP-3956025-A1 | CGRP ANTAGONISTS FOR THE TREATMENT OF MEDICATION OVERUSE HEADACHE, POST-TRAUMATIC HEADACHE, POST-CONCUSSION SYNDROME AND VERTIGO | Allergan Sales, LLC (US) | 2022-02-23 | — | — | EP | disclosed |