Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | ROS1 | P08922 | 3/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.44 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | BUB1 | O43683 | 1/20 | 0.44 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.44 |
| ▸ | STK16 | O75716 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10036431 | 0.82 | FGFR3 (0.51) | FLT3RETROS1ALKACVR1 | |
| SCHEMBL29399636 | 0.82 | HTT (0.48) | FLT3ACVR1MAPTKDM4EGAA | |
| SCHEMBL28685655 | 0.82 | HTT (0.48) | FLT3ACVR1MAPTKDM4EGAA | |
| SCHEMBL15244448 | 0.81 | KDM4E (0.43) | FLT3ALKEML4MAPTKDM4E | |
| SCHEMBL30019147 | 0.80 | MAPT (0.52) | HRH3PDE4ADRD3PTK2BMAPT | |
| SCHEMBL30019459 | 0.80 | MAPT (0.52) | HRH3DRD3PTK2BMAPTKDM4E | |
| SCHEMBL25797099 | 0.79 | MAPT (0.56) | RAF1BRAFMAPTKDM4EGAA | |
| SCHEMBL10127415 | 0.79 | FGFR3 (0.50) | FLT3RETROS1ALKACVR1 | |
| SCHEMBL29397031 | 0.79 | KDM4E (0.44) | MAPTKDM4ERAD52FGFR3 | |
| SCHEMBL17631428 | 0.79 | GAA (0.47) | FLT3RETROS1ALKACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110467637-B | Bisaminyl chloropyrimidine compound containing phosphine oxide substituted aniline, preparation method and application thereof | 北京赛特明强医药科技有限公司 | 2022-02-18 | — | — | CN | disclosed |