Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30019147 | 0.97 | MAPT (0.52) | MAPTKDM4ERAD52ALDH1A1L3MBTL1 | |
| SCHEMBL29399625 | 0.80 | FLT3 (0.46) | MAPTKDM4ERAD52GAAPTK2B | |
| SCHEMBL29517510 | 0.79 | MAPT (0.61) | MAPTKDM4ERAD52ALDH1A1L3MBTL1 | |
| SCHEMBL189143 | 0.79 | MAPT (0.61) | MAPTKDM4ERAD52ALDH1A1L3MBTL1 | |
| SCHEMBL30878657 | 0.77 | MAPT (0.49) | MAPTKDM4ERAD52ALDH1A1L3MBTL1 | |
| SCHEMBL25797099 | 0.77 | MAPT (0.56) | MAPTKDM4EALDH1A1L3MBTL1GAA | |
| SCHEMBL4297446 | 0.77 | MAPT (0.55) | MAPTKDM4ERAD52ALDH1A1L3MBTL1 | |
| SCHEMBL30879277 | 0.76 | NFE2L2 (0.50) | MAPTKDM4ERAD52ALDH1A1L3MBTL1 | |
| SCHEMBL30879017 | 0.76 | CYP19A1 (0.53) | MAPTKDM4EALDH1A1GAAKMT2A | |
| SCHEMBL25565665 | 0.75 | MAPT (0.56) | MAPTKDM4ERAD52ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226290-A1 | 2-PHENYLAMINO PYRROLOPYRIMIDINES AS ACK1 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2022-10-27 | — | — | WO | disclosed |