Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.39 |
| ▸ | SMO | Q99835 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2938505 | 0.90 | IGF1R (0.61) | IGF1RRXFP1SMONAMPTTP53 | |
| SCHEMBL2938933 | 0.87 | IGF1R (0.60) | IGF1RRXFP1SMONAMPT | |
| SCHEMBL2940258 | 0.87 | IGF1R (0.41) | IGF1RSMOLMNANPC1RAB9A | |
| SCHEMBL2938772 | 0.85 | IGF1R (0.57) | IGF1RRXFP1SMOSMN1; SMN2LMNA | |
| SCHEMBL2941779 | 0.85 | IGF1R (0.61) | IGF1RRXFP1SMOSMN1; SMN2LMNA | |
| SCHEMBL2937516 | 0.84 | IGF1R (0.63) | IGF1RRXFP1SMOSMN1; SMN2LMNA | |
| SCHEMBL2936312 | 0.84 | RXFP1 (0.39) | IGF1RRXFP1LMNANPC1RAB9A | |
| SCHEMBL2937464 | 0.84 | IGF1R (0.62) | IGF1RSMONAMPT | |
| SCHEMBL2938663 | 0.83 | IGF1R (0.58) | IGF1RRXFP1NAMPT | |
| SCHEMBL2937893 | 0.83 | IGF1R (0.62) | IGF1RRXFP1SMOPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |