Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 18/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 17/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL501218 | 0.94 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1LSS | |
| SCHEMBL501217 | 0.94 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1LSS | |
| SCHEMBL501035 | 0.92 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1LSS | |
| SCHEMBL501036 | 0.92 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1LSS | |
| SCHEMBL501329 | 0.89 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1LSS | |
| SCHEMBL500940 | 0.87 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1LSS | |
| SCHEMBL501332 | 0.87 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1 | |
| SCHEMBL501097 | 0.83 | LMNA (0.36) | HSP90AA1HSP90AB1MAPK1 | |
| SCHEMBL501055 | 0.81 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1 | |
| SCHEMBL500951 | 0.81 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113447-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113447-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | HSP90AB1, HSP90B1, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 1/4885LSS 1842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.