⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16851 | 0.96 | — | — | |
| SCHEMBL11126638 | 0.96 | CA1 (0.30) | — | |
| Fluoride SCHEMBL27474380 | 0.96 | — | — | |
| SCHEMBL5496029 | 0.93 | — | — | |
| SCHEMBL28610358 | 0.93 | — | — | |
| SCHEMBL28146323 | 0.93 | — | — | |
| Water SCHEMBL8763582 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL28169082 | 0.93 | — | — | |
| Hydrogen Peroxide SCHEMBL11746861 | 0.90 | — | — | |
| Benzene SCHEMBL28775548 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12441743-B2 | Spiro aromatic ring compound and use thereof | ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) | 2025-10-14 | — | — | US | disclosed |
| CN-118359642-A | Spiro aromatic ring compound and application thereof | 上海奕拓医药科技有限责任公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-111566104-B | Spiro aromatic ring compound and application thereof | 上海奕拓医药科技有限责任公司 | 2024-05-17 | — | — | CN | disclosed |
| US-20240116949-A1 | SPIRO AROMATIC RING COMPOUND AND USE THEREOF | ETERN BIOPHARMA SHANGHAI CO LTD (CN) | 2024-04-11 | — | — | US | disclosed |
| US-11685748-B2 | Spiro aromatic ring compound and application thereof | ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) | 2023-06-27 | — | — | US | disclosed |
| EP-3712151-B1 | (S)-1'-(8-((2-AMINO-3-CHLOROPYRIDIN-4-YL)THIO)IMIDAZO[1,2-C]PYRIMIDIN-5-YL)-5,7-DIHYDROSPIRO[CYCLOPENTA[B]PYRIDINE-6,4'-PIPERIDINE]-5-AMINE AS SHP2 INHIBITOR FOR THE TREATMENT OF CANCER | ETERN BIOPHARMA SHANGHAI CO LTD (CN) | 2022-03-02 | — | — | EP | disclosed |