SCHEMBL29402425

SCHEMBL29402425

COc1cccc2ccc3[nH]c(C(=O)c4ccc(N)c(F)c4)cc3c12

nearest known ligand 0.49

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 9/20 0.49
MEN1 O00255 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2303473 1.00 FLT3 (0.49) FLT3MEN1NPC1RAB9AKMT2A
SCHEMBL30008168 0.91 FLT3 (0.52) FLT3MEN1NPC1RAB9AKMT2A
SCHEMBL2301216 0.91 FLT3 (0.52) FLT3MEN1NPC1RAB9AKMT2A
SCHEMBL29402151 0.86 FLT3 (0.54) FLT3MEN1KMT2A
SCHEMBL2302040 0.86 FLT3 (0.54) FLT3MEN1KMT2A
SCHEMBL2301607 0.82 FLT3 (0.49) FLT3
SCHEMBL29400009 0.82 FLT3 (0.49) FLT3
SCHEMBL2301360 0.80 ALDH1A1 (0.56) FLT3MEN1NPC1RAB9AKMT2A
SCHEMBL29402574 0.80 ALDH1A1 (0.56) FLT3MEN1NPC1RAB9AKMT2A
SCHEMBL2301433 0.79 MEN1 (0.42) FLT3MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4340897-A1 METHODS AND COMPOSITIONS FOR TREATING PANCREATIC AND HEPATIC DISEASE METANOIA BIO INC. (US) 2024-03-27 EP disclosed
EP-4340835-A1 METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASE METANOIA BIO INC. (US) 2024-03-27 EP disclosed
EP-4340896-A1 METHODS AND COMPOSITIONS FOR TREATING OCULAR NEOVASCULAR DISEASE METANOIA BIO INC. (US) 2024-03-27 EP disclosed
EP-4340836-A1 METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL CONDITIONS METANOIA BIO INC. (US) 2024-03-27 EP disclosed
CN-116615241-A Methods and compositions for diabetes treatment and beta cell regeneration 加利福尼亚大学董事会 2023-08-18 CN disclosed
EP-4200016-A1 METHODS AND COMPOSITIONS FOR DIABETES TREATMENT AND BETA-CELL REGENERATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-06-28 EP disclosed
WO-2022245711-A1 METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL CONDITIONS METANOIA BIO INC. (US) 2022-11-24 WO disclosed
WO-2022245698-A1 METHODS AND COMPOSITIONS FOR TREATING PANCREATIC AND HEPATIC DISEASE METANOIA BIO INC. (US) 2022-11-24 WO disclosed
WO-2022245702-A1 METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASE METANOIA BIO INC. (US) 2022-11-24 WO disclosed
WO-2022245697-A1 METHODS AND COMPOSITIONS FOR TREATING OCULAR NEOVASCULAR DISEASE METANOIA BIO INC. (US) 2022-11-24 WO disclosed
WO-2022040161-A1 METHODS AND COMPOSITIONS FOR DIABETES TREATMENT AND BETA-CELL REGENERATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-02-24 WO disclosed